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MedKoo Cat#: 565692 | Name: MGR1
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

MGR1 is a novel ros-generating probe.

Chemical Structure

MGR1
MGR1
CAS# 2361529-46-4

Theoretical Analysis

MedKoo Cat#: 565692

Name: MGR1

CAS#: 2361529-46-4

Chemical Formula: C22H24O5

Exact Mass: 368.1624

Molecular Weight: 368.43

Elemental Analysis: C, 71.72; H, 6.57; O, 21.71

Price and Availability

Size Price Availability Quantity
5mg USD 350.00 2 weeks
25mg USD 975.00 2 Weeks
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Related CAS #
No Data
Synonym
MGR1; MGR 1; MGR-1
IUPAC/Chemical Name
((9,10-Dioxo-1,4,4a,9,9a,10-hexahydro-1,4-ethanoanthracen-5-yl)oxy)methyl pivalate
InChi Key
XOQBQESWHYEJGY-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H24O5/c1-22(2,3)21(25)27-11-26-15-6-4-5-14-18(15)20(24)17-13-9-7-12(8-10-13)16(17)19(14)23/h4-7,9,12-13,16-17H,8,10-11H2,1-3H3
SMILES Code
CC(C)(C)C(OCOC1=CC=CC2=C1C(C3C(CC4)C=CC4C3C2=O)=O)=O
Appearance
Solid
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 368.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Yan W, Long P, Chen T, Liu W, Yao L, Ren Z, Li X, Wang J, Xue J, Tao Y, Zhang L, Zhang Z. A Natural Occurring Mouse Model with Adgrv1 Mutation of Usher Syndrome 2C and Characterization of its Recombinant Inbred Strains. Cell Physiol Biochem. 2018;47(5):1883-1897. doi: 10.1159/000491068. Epub 2018 Jun 29. PubMed PMID: 29961073. 2: Wu X, Li L, Jiang H. Mitochondrial inner-membrane protease Yme1 degrades outer-membrane proteins Tom22 and Om45. J Cell Biol. 2018 Jan 2;217(1):139-149. doi: 10.1083/jcb.201702125. Epub 2017 Nov 14. PubMed PMID: 29138251; PubMed Central PMCID: PMC5748973. 3: Shin D, Lin ST, Fu YH, Ptácek LJ. Very large G protein-coupled receptor 1 regulates myelin-associated glycoprotein via Gαs/Gαq-mediated protein kinases A/C. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):19101-6. doi: 10.1073/pnas.1318501110. Epub 2013 Nov 4. PubMed PMID: 24191038; PubMed Central PMCID: PMC3839775. 4: Zallocchi M, Delimont D, Meehan DT, Cosgrove D. Regulated vesicular trafficking of specific PCDH15 and VLGR1 variants in auditory hair cells. J Neurosci. 2012 Oct 3;32(40):13841-59. doi: 10.1523/JNEUROSCI.1242-12.2012. PubMed PMID: 23035094; PubMed Central PMCID: PMC3505989. 5: Urano T, Shiraki M, Yagi H, Ito M, Sasaki N, Sato M, Ouchi Y, Inoue S. GPR98/Gpr98 gene is involved in the regulation of human and mouse bone mineral density. J Clin Endocrinol Metab. 2012 Apr;97(4):E565-74. doi: 10.1210/jc.2011-2393. Epub 2012 Mar 14. PubMed PMID: 22419726. 6: Zallocchi M, Meehan DT, Delimont D, Rutledge J, Gratton MA, Flannery J, Cosgrove D. Role for a novel Usher protein complex in hair cell synaptic maturation. PLoS One. 2012;7(2):e30573. doi: 10.1371/journal.pone.0030573. Epub 2012 Feb 17. PubMed PMID: 22363448; PubMed Central PMCID: PMC3281840. 7: Yagi H, Noguchi Y, Kitamura K, Sato M. Deficiency of Vlgr1 resulted in deafness and susceptibility to audiogenic seizures while the degree of hearing impairment was not correlated with seizure severity in C57BL/6- and 129-backcrossed lines of Vlgr1 knockout mice. Neurosci Lett. 2009 Sep 18;461(2):190-5. doi: 10.1016/j.neulet.2009.06.012. Epub 2009 Jun 17. PubMed PMID: 19539720. 8: Dunn CD, Tamura Y, Sesaki H, Jensen RE. Mgr3p and Mgr1p are adaptors for the mitochondrial i-AAA protease complex. Mol Biol Cell. 2008 Dec;19(12):5387-97. doi: 10.1091/mbc.E08-01-0103. Epub 2008 Oct 8. PubMed PMID: 18843051; PubMed Central PMCID: PMC2592643. 9: Yagi H, Tokano H, Maeda M, Takabayashi T, Nagano T, Kiyama H, Fujieda S, Kitamura K, Sato M. Vlgr1 is required for proper stereocilia maturation of cochlear hair cells. Genes Cells. 2007 Feb;12(2):235-50. PubMed PMID: 17295842. 10: van Wijk E, van der Zwaag B, Peters T, Zimmermann U, Te Brinke H, Kersten FF, Märker T, Aller E, Hoefsloot LH, Cremers CW, Cremers FP, Wolfrum U, Knipper M, Roepman R, Kremer H. The DFNB31 gene product whirlin connects to the Usher protein network in the cochlea and retina by direct association with USH2A and VLGR1. Hum Mol Genet. 2006 Mar 1;15(5):751-65. Epub 2006 Jan 24. PubMed PMID: 16434480. 11: Klein BD, Fu YH, Ptacek LJ, White HS. Auditory deficits associated with the frings mgr1 (mass1) mutation in mice. Dev Neurosci. 2005;27(5):321-32. PubMed PMID: 16137990. 12: Yagi H, Takamura Y, Yoneda T, Konno D, Akagi Y, Yoshida K, Sato M. Vlgr1 knockout mice show audiogenic seizure susceptibility. J Neurochem. 2005 Jan;92(1):191-202. PubMed PMID: 15606908. 13: McMillan DR, White PC. Loss of the transmembrane and cytoplasmic domains of the very large G-protein-coupled receptor-1 (VLGR1 or Mass1) causes audiogenic seizures in mice. Mol Cell Neurosci. 2004 Jun;26(2):322-9. PubMed PMID: 15207856. 14: Cader ZM, Noble-Topham S, Dyment DA, Cherny SS, Brown JD, Rice GP, Ebers GC. Significant linkage to migraine with aura on chromosome 11q24. Hum Mol Genet. 2003 Oct 1;12(19):2511-7. Epub 2003 Jul 29. PubMed PMID: 12915447. 15: Scheel H, Tomiuk S, Hofmann K. A common protein interaction domain links two recently identified epilepsy genes. Hum Mol Genet. 2002 Jul 15;11(15):1757-62. PubMed PMID: 12095917.