AZ4 | CAS#N/A | selective inhibitor

MedKoo Cat#: 565691 | Name: AZ4

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AZ4 is a first-in-class highly selective inhibitor of pi3kγ, binding to an active state and exhibiting over 1000 fold of selectivity over pi3kα and pi3kβ

Chemical Structure

AZ4

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 565691

Name: AZ4

CAS#: N/A

Chemical Formula: C19H22N4O4S2

Exact Mass: 434.1082

Molecular Weight: 434.53

Elemental Analysis: C, 52.52; H, 5.10; N, 12.89; O, 14.73; S, 14.76

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

AZ4; AZ 4; AZ-4

IUPAC/Chemical Name

(S)-N-(5-(2-(1-Cyclopropylethyl)-1-oxo-7-sulfamoylisoindolin-5-yl)-4-methylthiazol-2-yl)acetamide

InChi Key

NHFRWRZPNNFBRN-JTQLQIEISA-N

InChi Code

InChI=1S/C19H22N4O4S2/c1-9-17(28-19(21-9)22-11(3)24)13-6-14-8-23(10(2)12-4-5-12)18(25)16(14)15(7-13)29(20,26)27/h6-7,10,12H,4-5,8H2,1-3H3,(H2,20,26,27)(H,21,22,24)/t10-/m0/s1

SMILES Code

CC(NC1=NC(C)=C(C2=CC3=C(C(N([C@H](C4CC4)C)C3)=O)C(S(=O)(N)=O)=C2)S1)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 434.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Zhu Q, Wang S, Chen P. Diazocine Derivatives: A Family of Azobenzenes for Photochromism with Highly Enhanced Turn-On Fluorescence. Org Lett. 2019 Jun 7;21(11):4025-4029. doi: 10.1021/acs.orglett.9b01215. Epub 2019 May 14. PubMed PMID: 31084009. 2: Khadse S, Ugale V, Talele G. Rational Design and Synthesis of Benzamides as Non-ulcerogenic Anti-inflammatory Agents. Antiinflamm Antiallergy Agents Med Chem. 2015;13(3):174-87. PubMed PMID: 25323059. 3: Khadse SC, Talele GS, Agrawal SS. Aminocarbonyl arylvinylbenzamides as gastric sparing anti-inflammatory agents. Arch Pharm (Weinheim). 2011 May;344(5):292-300. doi: 10.1002/ardp.201000096. Epub 2011 Feb 2. PubMed PMID: 21290431. 4: Couto N, Ramos MJ, Fernandez MT, Rodrigues P, Barros MT, Costa ML, Cabral BJ, Duarte MF. Study of doubly charged alkaline earth metal and 3-azidopropionitrile complexes by electrospray ionization mass spectrometry. Rapid Commun Mass Spectrom. 2008;22(4):582-90. doi: 10.1002/rcm.3397. PubMed PMID: 18220327. 5: Shyu KG, Huang ST, Kuo HS, Cheng WP, Lin YL. Antitumor activity of a novel bis-aziridinylnaphthoquinone (AZ4) mediating cell cycle arrest and apoptosis in non-small cell lung cancer cell line NCI-H460. Acta Pharmacol Sin. 2007 Apr;28(4):559-66. PubMed PMID: 17376296.