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MedKoo Cat#: 565660 | Name: Ant4

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ant4 is a novel inhibitor of polyamine (PA) transport, showing a high trypanocidal effect alone or combined with benznidazole, being a promising compound for the treatment of Chagas disease

Chemical Structure

Ant4
Ant4
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 565660

Name: Ant4

CAS#: N/A

Chemical Formula: C19H24Cl2N2

Exact Mass: 350.1317

Molecular Weight: 351.32

Elemental Analysis: C, 64.96; H, 6.89; Cl, 20.18; N, 7.97

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Ant4; Ant 4; Ant-4
IUPAC/Chemical Name
N1-(Anthracen-9-ylmethyl)butane-1,4-diamine Dihydrochloride
InChi Key
SMKJNUOLUJELSZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H22N2.2ClH/c20-11-5-6-12-21-14-19-17-9-3-1-7-15(17)13-16-8-2-4-10-18(16)19;;/h1-4,7-10,13,21H,5-6,11-12,14,20H2;2*1H
SMILES Code
NCCCCNCC1=C2C=CC=CC2=CC3=CC=CC=C13.[H]Cl.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 351.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Lim CH, Brower JV, Resnick JL, Oh SP, Terada N. Adenine nucleotide translocase 4 is expressed within embryonic ovaries and dispensable during oogenesis. Reprod Sci. 2015 Feb;22(2):250-7. doi: 10.1177/1933719114542026. Epub 2014 Jul 16. PubMed PMID: 25031318; PubMed Central PMCID: PMC4287603. 2: Palmieri F. The mitochondrial transporter family SLC25: identification, properties and physiopathology. Mol Aspects Med. 2013 Apr-Jun;34(2-3):465-84. doi: 10.1016/j.mam.2012.05.005. Epub 2012 Dec 23. Review. PubMed PMID: 23266187. 3: Lim CH, Hamazaki T, Braun EL, Wade J, Terada N. Evolutionary genomics implies a specific function of Ant4 in mammalian and anole lizard male germ cells. PLoS One. 2011;6(8):e23122. doi: 10.1371/journal.pone.0023122. Epub 2011 Aug 12. PubMed PMID: 21858006; PubMed Central PMCID: PMC3155547. 4: Dupont PY, Stepien G. Computational analysis of the transcriptional regulation of the adenine nucleotide translocator isoform 4 gene and its role in spermatozoid glycolytic metabolism. Gene. 2011 Nov 1;487(1):38-45. doi: 10.1016/j.gene.2011.07.024. Epub 2011 Jul 31. PubMed PMID: 21827840. 5: Hamazaki T, Leung WY, Cain BD, Ostrov DA, Thorsness PE, Terada N. Functional expression of human adenine nucleotide translocase 4 in Saccharomyces cerevisiae. PLoS One. 2011 Apr 21;6(4):e19250. doi: 10.1371/journal.pone.0019250. PubMed PMID: 21532989; PubMed Central PMCID: PMC3080916. 6: Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. PLoS One. 2010 Sep 21;5(9):e12862. doi: 10.1371/journal.pone.0012862. PubMed PMID: 20877624; PubMed Central PMCID: PMC2943476. 7: Gallerne C, Touat Z, Chen ZX, Martel C, Mayola E, Sharaf el dein O, Buron N, Le Bras M, Jacotot E, Borgne-Sanchez A, Lemoine A, Lemaire C, Pervaiz S, Brenner C. The fourth isoform of the adenine nucleotide translocator inhibits mitochondrial apoptosis in cancer cells. Int J Biochem Cell Biol. 2010 May;42(5):623-9. doi: 10.1016/j.biocel.2009.12.024. Epub 2010 Jan 10. PubMed PMID: 20060930. 8: Brower JV, Lim CH, Jorgensen M, Oh SP, Terada N. Adenine nucleotide translocase 4 deficiency leads to early meiotic arrest of murine male germ cells. Reproduction. 2009 Sep;138(3):463-70. doi: 10.1530/REP-09-0201. Epub 2009 Jun 25. PubMed PMID: 19556438; PubMed Central PMCID: PMC3727218. 9: Brower JV, Rodic N, Seki T, Jorgensen M, Fliess N, Yachnis AT, McCarrey JR, Oh SP, Terada N. Evolutionarily conserved mammalian adenine nucleotide translocase 4 is essential for spermatogenesis. J Biol Chem. 2007 Oct 5;282(40):29658-66. Epub 2007 Aug 6. PubMed PMID: 17681941. 10: Kim YH, Haidl G, Schaefer M, Egner U, Mandal A, Herr JC. Compartmentalization of a unique ADP/ATP carrier protein SFEC (Sperm Flagellar Energy Carrier, AAC4) with glycolytic enzymes in the fibrous sheath of the human sperm flagellar principal piece. Dev Biol. 2007 Feb 15;302(2):463-76. Epub 2006 Oct 10. PubMed PMID: 17137571; PubMed Central PMCID: PMC1858657.

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