Synonym
AM6701; AM 6701; AM-6701; LY2183240 2’-isomer
IUPAC/Chemical Name
5-(4-Biphenylylmethyl)-N,N-dimethyl-2H-tetrazole-2-carboxamide
InChi Key
VBVLSXPOMAONNK-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H17N5O/c1-21(2)17(23)22-19-16(18-20-22)12-13-8-10-15(11-9-13)14-6-4-3-5-7-14/h3-11H,12H2,1-2H3
SMILES Code
O=C(N1N=C(CC2=CC=C(C3=CC=CC=C3)C=C2)N=N1)N(C)C
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
307.36
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Shields CM, Zvonok N, Zvonok A, Makriyannis A. Biochemical and Proteomic Characterization of Recombinant Human α/β Hydrolase Domain 6. Sci Rep. 2019 Jan 29;9(1):890. doi: 10.1038/s41598-018-36633-4. PubMed PMID: 30696836; PubMed Central PMCID: PMC6351631.
2: Karageorgos I, Wales TE, Janero DR, Zvonok N, Vemuri VK, Engen JR, Makriyannis A. Active-site inhibitors modulate the dynamic properties of human monoacylglycerol lipase: a hydrogen exchange mass spectrometry study. Biochemistry. 2013 Jul 23;52(29):5016-26. doi: 10.1021/bi400430k. Epub 2013 Jul 8. PubMed PMID: 23795559; PubMed Central PMCID: PMC3855488.
3: West JM, Zvonok N, Whitten KM, Vadivel SK, Bowman AL, Makriyannis A. Biochemical and mass spectrometric characterization of human N-acylethanolamine-hydrolyzing acid amidase inhibition. PLoS One. 2012;7(8):e43877. doi: 10.1371/journal.pone.0043877. Epub 2012 Aug 31. PubMed PMID: 22952796; PubMed Central PMCID: PMC3432061.
4: Naidoo V, Karanian DA, Vadivel SK, Locklear JR, Wood JT, Nasr M, Quizon PM, Graves EE, Shukla V, Makriyannis A, Bahr BA. Equipotent inhibition of fatty acid amide hydrolase and monoacylglycerol lipase - dual targets of the endocannabinoid system to protect against seizure pathology. Neurotherapeutics. 2012 Oct;9(4):801-13. doi: 10.1007/s13311-011-0100-y. PubMed PMID: 22270809; PubMed Central PMCID: PMC3480564.
5: Karageorgos I, Tyukhtenko S, Zvonok N, Janero DR, Sallum C, Makriyannis A. Identification by nuclear magnetic resonance spectroscopy of an active-site hydrogen-bond network in human monoacylglycerol lipase (hMGL): implications for hMGL dynamics, pharmacological inhibition, and catalytic mechanism. Mol Biosyst. 2010 Aug;6(8):1381-8. doi: 10.1039/c004515b. Epub 2010 May 12. PubMed PMID: 20464001; PubMed Central PMCID: PMC3697746.
6: Zvonok N, Pandarinathan L, Williams J, Johnston M, Karageorgos I, Janero DR, Krishnan SC, Makriyannis A. Covalent inhibitors of human monoacylglycerol lipase: ligand-assisted characterization of the catalytic site by mass spectrometry and mutational analysis. Chem Biol. 2008 Aug 25;15(8):854-62. doi: 10.1016/j.chembiol.2008.06.008. PubMed PMID: 18721756; PubMed Central PMCID: PMC3972761.
