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MedKoo Cat#: 565631 | Name: BOEPL

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BOEPL is a modified nbi42902 as an antagonist of luteinizing hormone releasing hormone receptor (lhrh-r) and to be able to link with a near infrared dye for imaging lhrh receptor positive cancers

Chemical Structure

BOEPL
BOEPL
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 565631

Name: BOEPL

CAS#: N/A

Chemical Formula: C29H27F2N3O4

Exact Mass: 519.1970

Molecular Weight: 519.55

Elemental Analysis: C, 67.04; H, 5.24; F, 7.31; N, 8.09; O, 12.32

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
BOEPL (Breast, Ovarian, Endometrial, and Prostate Cancer Ligand)
IUPAC/Chemical Name
(R)-3-(3-(3-(2-Amino-2-phenylethyl)-1-(2,6-difluorobenzyl)-6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)phenyl)propanoic acid
InChi Key
NFZVFQNKUATCFO-VWLOTQADSA-N
InChi Code
InChI=1S/C29H27F2N3O4/c1-18-27(21-10-5-7-19(15-21)13-14-26(35)36)28(37)34(17-25(32)20-8-3-2-4-9-20)29(38)33(18)16-22-23(30)11-6-12-24(22)31/h2-12,15,25H,13-14,16-17,32H2,1H3,(H,35,36)/t25-/m0/s1
SMILES Code
O=C(O)CCC1=CC=CC(C2=C(C)N(CC3=C(F)C=CC=C3F)C(N(C[C@H](N)C4=CC=CC=C4)C2=O)=O)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 519.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Roy J, Kaake M, Low PS. Small molecule targeted NIR dye conjugate for imaging LHRH receptor positive cancers. Oncotarget. 2019 Jan 4;10(2):152-160. doi: 10.18632/oncotarget.26520. eCollection 2019 Jan 4. PubMed PMID: 30719210; PubMed Central PMCID: PMC6349437. 2: Roy J, Kaake M, Srinivasarao M, Low PS. Targeted Tubulysin B Hydrazide Conjugate for the Treatment of Luteinizing Hormone-Releasing Hormone Receptor-Positive Cancers. Bioconjug Chem. 2018 Jul 18;29(7):2208-2214. doi: 10.1021/acs.bioconjchem.8b00164. Epub 2018 Jun 13. PubMed PMID: 29851465.