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MedKoo Cat#: 565592 | Name: BAA473

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BAA473 is a novel activator of pyrin inflammasome, inducing secretion of interleukin-18 (il18) in both myeloid and intestinal epithelial cells

Chemical Structure

BAA473
BAA473
CAS#20231-68-9

Theoretical Analysis

MedKoo Cat#: 565592

Name: BAA473

CAS#: 20231-68-9

Chemical Formula: C25H40O5

Exact Mass: 420.2876

Molecular Weight: 420.59

Elemental Analysis: C, 71.39; H, 9.59; O, 19.02

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
BAA473; BAA 473; BAA-473; 11-Oxo-12S-hydroxy lithocholic acid methyl ester;
IUPAC/Chemical Name
Methyl (R)-4-((3R,5R,8S,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-11-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate
InChi Key
RYGJYUKSMUSEMY-SLKGKNCKSA-N
InChi Code
InChI=1S/C25H40O5/c1-14(5-10-20(27)30-4)18-8-9-19-17-7-6-15-13-16(26)11-12-24(15,2)21(17)22(28)23(29)25(18,19)3/h14-19,21,23,26,29H,5-13H2,1-4H3/t14-,15-,16-,17+,18-,19+,21-,23-,24+,25-/m1/s1
SMILES Code
C[C@@H]([C@H]([C@@]1(C)[C@@H]2O)CC[C@@]1([H])[C@]3([H])CC[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])C2=O)CCC(OC)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 420.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Falcone EL, Bryant C. Let's get this pyrin started! J Biol Chem. 2019 Mar 8;294(10):3367-3368. doi: 10.1074/jbc.H119.007830. Review. PubMed PMID: 30850508; PubMed Central PMCID: PMC6416431. 2: Alimov I, Menon S, Cochran N, Maher R, Wang Q, Alford J, Concannon JB, Yang Z, Harrington E, Llamas L, Lindeman A, Hoffman G, Schuhmann T, Russ C, Reece-Hoyes J, Canham SM, Cai X. Bile acid analogues are activators of pyrin inflammasome. J Biol Chem. 2019 Mar 8;294(10):3359-3366. doi: 10.1074/jbc.RA118.005103. Epub 2019 Jan 15. PubMed PMID: 30647128; PubMed Central PMCID: PMC6416436.