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MedKoo Cat#: 565517 | Name: Levocarnitine Propionate Hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Levocarnitine Propionate Hydrochloride is a natural carnitine derivative, playing a role in mitochondrial metabolism and demonstrating beneficial cardiovascular effects

Chemical Structure

Levocarnitine Propionate Hydrochloride
CAS#119793-66-7 (HCl)

Theoretical Analysis

MedKoo Cat#: 565517

Name: Levocarnitine Propionate Hydrochloride

CAS#: 119793-66-7 (HCl)

Chemical Formula: C10H20ClNO4

Exact Mass: 253.1081

Molecular Weight: 253.72

Elemental Analysis: C, 47.34; H, 7.95; Cl, 13.97; N, 5.52; O, 25.22

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
IUPAC/Chemical Name
[(2R)-3-Carboxy-2-propanoyloxypropyl]-trimethylazanium chloride
InChi Key
KTFMPDDJYRFWQE-DDWIOCJRSA-N
InChi Code
InChI=1S/C10H19NO4.ClH/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4;/h8H,5-7H2,1-4H3;1H/t8-;/m1./s1
SMILES Code
C[N+](C)(C[C@H](OC(CC)=O)CC(O)=O)C.[Cl-]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Levocarnitine propionate hydrochloride (L-Propionylcarnitine chloride; ST-261) is used to treat the deterioration of renal function, congestive heart failure, intermittent claudication, and other diseases.
In vitro activity:
In the following, cells were treated with LC (L-Carnitine) and at the end of the treatment period, the cells were subjected to the real-time PCR technique along with western blotting assay for measurement of the telomere length and assessment of protein expression, respectively. The results showed that 0.2 mM LC caused the elongation of the telomere length and increased the TERT protein expression. Reference: Curr Stem Cell Res Ther. 2022 May 11. https://pubmed.ncbi.nlm.nih.gov/35546751/
In vivo activity:
Inflammation at the tissue level was also mildest in group A, and severest in the group that was not given carnitine (group C). All of the study groups and the control group differed significantly with respect to inflammation scores. In conclusion, L-carnitine improved oxygen saturation, and decreased urine leukotriene E4 levels and inflammation in lung tissues in the present murine model of asthma. Reference: Acta Med Okayama. 2002 Dec;56(6):295-301. https://pubmed.ncbi.nlm.nih.gov/12685858/
Solvent mg/mL mM comments
Solubility
DMF 15.0 59.12
DMSO 135.0 532.08
Ethanol 25.0 98.53
PBS (pH 7.2) 10.0 39.41
Water 60.0 236.48
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 253.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Fathi E, Montazersaheb S, Sanaat Z, Nakhlband A, Vandghanooni S, Farahzadi R, Vietor I. L-carnitine reduced cellular aging of bone marrow resident C-kit+ hematopoietic stem cells through telomere dependent pathways. Curr Stem Cell Res Ther. 2022 May 11. doi: 10.2174/1574888X17666220511141123. Epub ahead of print. PMID: 35546751. 2. Lee YG, Chou HC, Chen YT, Tung SY, Ko TL, Buyandelger B, Wen LL, Juan SH. L-Carnitine reduces reactive oxygen species/endoplasmic reticulum stress and maintains mitochondrial function during autophagy-mediated cell apoptosis in perfluorooctanesulfonate-treated renal tubular cells. Sci Rep. 2022 Mar 18;12(1):4673. doi: 10.1038/s41598-022-08771-3. PMID: 35304586; PMCID: PMC8933466. 3. Dehghani A, Pourjafari F, Koohkan F, Haghpanh T, Pourjafari F, Sheibani V, Afarinesh MR. L-carnitine attenuates acoustic startle reflex dysfunction in adult male rats exposed to mancozeb. Toxicol Ind Health. 2023 Jan 17:7482337231151739. doi: 10.1177/07482337231151739. Epub ahead of print. PMID: 36650049. 4. Uzuner N, Kavukçu S, Yilmaz O, Ozkal S, Işlekel H, Karaman O, Soylu A, Kargi A. The role of L-carnitine in treatment of a murine model of asthma. Acta Med Okayama. 2002 Dec;56(6):295-301. doi: 10.18926/AMO/31692. PMID: 12685858.
In vitro protocol:
1. Fathi E, Montazersaheb S, Sanaat Z, Nakhlband A, Vandghanooni S, Farahzadi R, Vietor I. L-carnitine reduced cellular aging of bone marrow resident C-kit+ hematopoietic stem cells through telomere dependent pathways. Curr Stem Cell Res Ther. 2022 May 11. doi: 10.2174/1574888X17666220511141123. Epub ahead of print. PMID: 35546751. 2. Lee YG, Chou HC, Chen YT, Tung SY, Ko TL, Buyandelger B, Wen LL, Juan SH. L-Carnitine reduces reactive oxygen species/endoplasmic reticulum stress and maintains mitochondrial function during autophagy-mediated cell apoptosis in perfluorooctanesulfonate-treated renal tubular cells. Sci Rep. 2022 Mar 18;12(1):4673. doi: 10.1038/s41598-022-08771-3. PMID: 35304586; PMCID: PMC8933466.
In vivo protocol:
1. Dehghani A, Pourjafari F, Koohkan F, Haghpanh T, Pourjafari F, Sheibani V, Afarinesh MR. L-carnitine attenuates acoustic startle reflex dysfunction in adult male rats exposed to mancozeb. Toxicol Ind Health. 2023 Jan 17:7482337231151739. doi: 10.1177/07482337231151739. Epub ahead of print. PMID: 36650049. 2. Uzuner N, Kavukçu S, Yilmaz O, Ozkal S, Işlekel H, Karaman O, Soylu A, Kargi A. The role of L-carnitine in treatment of a murine model of asthma. Acta Med Okayama. 2002 Dec;56(6):295-301. doi: 10.18926/AMO/31692. PMID: 12685858.

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