MedKoo Cat#: 565473 | Name: Sphynolactone-7
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Sphynolactone-7 is a novel selective and highly potent strigolactone agonist, activating a high-affinity strigolactone receptor shhtl7 to provoke striga germination with potency in the femtomolar range.

Chemical Structure

Sphynolactone-7
Sphynolactone-7
CAS#2305752-57-0

Theoretical Analysis

MedKoo Cat#: 565473

Name: Sphynolactone-7

CAS#: 2305752-57-0

Chemical Formula: C20H26N2O7S

Exact Mass: 438.1461

Molecular Weight: 438.50

Elemental Analysis: C, 54.78; H, 5.98; N, 6.39; O, 25.54; S, 7.31

Price and Availability

Size Price Availability Quantity
5mg USD 550.00 2 weeks
10mg USD 1,000.00 2 Weeks
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Related CAS #
No Data
Synonym
SPL7; Sphynolactone-7; Sphynolactone 7; Sphynolactone7
IUPAC/Chemical Name
4-Methyl-5-oxo-2,5-dihydrofuran-2-yl 4-((4-butoxyphenyl)sulfonyl)piperazine-1-carboxylate
InChi Key
GGAPQPVAXJSNFU-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H26N2O7S/c1-3-4-13-27-16-5-7-17(8-6-16)30(25,26)22-11-9-21(10-12-22)20(24)29-18-14-15(2)19(23)28-18/h5-8,14,18H,3-4,9-13H2,1-2H3
SMILES Code
O=C(N1CCN(S(=O)(C2=CC=C(OCCCC)C=C2)=O)CC1)OC(C=C3C)OC3=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Biological target:
Sphynolactone-7 selectively binds to ShHTL7 (IC50 = 0.31 µM) over ShHTL2-6, ShHTL9-10, and the strigolactone receptor AtD14 at 10 µM but does inhibit ShHTL8 and ShHTL11 (IC50s = 1.2 and 7.8 µM, respectively).
In vitro activity:
To be determined
In vivo activity:
This study demonstrated that sphynolactone-7 is effective for reducing the parasitic plant Striga parasitism without impinging on host strigolactone-related processes. Sphynolactone-7 provoked Striga germination with potency in the femtomolar range. Reference: Science. 2018 Dec 14;362(6420):1301-1305. https://pubmed.ncbi.nlm.nih.gov/30545887/

Preparing Stock Solutions

The following data is based on the product molecular weight 438.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Uraguchi D, Kuwata K, Hijikata Y, Yamaguchi R, Imaizumi H, Am S, Rakers C, Mori N, Akiyama K, Irle S, McCourt P, Kinoshita T, Ooi T, Tsuchiya Y. A femtomolar-range suicide germination stimulant for the parasitic plant Striga hermonthica. Science. 2018 Dec 14;362(6420):1301-1305. doi: 10.1126/science.aau5445. PMID: 30545887.
In vitro protocol:
To be determined
In vivo protocol:
1. Uraguchi D, Kuwata K, Hijikata Y, Yamaguchi R, Imaizumi H, Am S, Rakers C, Mori N, Akiyama K, Irle S, McCourt P, Kinoshita T, Ooi T, Tsuchiya Y. A femtomolar-range suicide germination stimulant for the parasitic plant Striga hermonthica. Science. 2018 Dec 14;362(6420):1301-1305. doi: 10.1126/science.aau5445. PMID: 30545887.
1: Uraguchi D, Kuwata K, Hijikata Y, Yamaguchi R, Imaizumi H, Am S, Rakers C, Mori N, Akiyama K, Irle S, McCourt P, Kinoshita T, Ooi T, Tsuchiya Y. A femtomolar-range suicide germination stimulant for the parasitic plant Striga hermonthica. Science. 2018 Dec 14;362(6420):1301-1305. doi: 10.1126/science.aau5445. PubMed PMID: 30545887.