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MedKoo Cat#: 585028 | Name: Plomestane

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Plomestane is a selective inhibitor of aromatization in human breast tissue and may provide a mechanism for controlling estrogen responsive processes.

Chemical Structure

Plomestane
Plomestane
CAS#77016-85-4

Theoretical Analysis

MedKoo Cat#: 585028

Name: Plomestane

CAS#: 77016-85-4

Chemical Formula: C21H26O2

Exact Mass: 310.1933

Molecular Weight: 310.44

Elemental Analysis: C, 81.25; H, 8.44; O, 10.31

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Plomestane; MDL 18,962
IUPAC/Chemical Name
Estr-4-ene-3,17-dione, 10-(2-propynyl)-
InChi Key
JKPDEYAOCSQBSZ-OEUJLIAZSA-N
InChi Code
InChI=1S/C21H26O2/c1-3-10-21-12-8-15(22)13-14(21)4-5-16-17-6-7-19(23)20(17,2)11-9-18(16)21/h1,13,16-18H,4-12H2,2H3/t16-,17-,18-,20-,21-/m0/s1
SMILES Code
C[C@]1([C@](CC2)([H])[C@]3([H])CCC4=CC(CC[C@]4(CC#C)[C@@]3([H])CC1)=O)C2=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 310.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Perel E, Davis SP, Covey DF, Killinger DW. Effects of 4-hydroxy-4-androstene-3, 17-dione and 10-propargylestr-4-ene-3, 17-dione on the metabolism of androstenedione in human breast carcinoma and breast adipose tissues. Steroids. 1981 Oct;38(4):397-405. PubMed PMID: 7314156. 2: Johnston JO, Wright CL, Holbert GW. Enzyme-activated inhibitors of steroidal hydroxylases. J Steroid Biochem Mol Biol. 1995 Jan;52(1):17-34. PubMed PMID: 7857870. 3: MacIndoe JH, Woods GR, Etre LA, Covey DF. Comparative studies of aromatase inhibitors in cultured human breast cancer cells. Cancer Res. 1982 Aug;42(8 Suppl):3378s-3381s. PubMed PMID: 7083203. 4: Longcope C, Femino A, Johnston JO. Inhibition of peripheral aromatization in baboons by an enzyme-activated aromatase inhibitor (MDL 18,962). Endocrinology. 1988 May;122(5):2007-11. PubMed PMID: 3359974. 5: White EL, Ross LJ, Steele VE, Kelloff GJ, Hill DL. Screening of potential cancer preventing chemicals as aromatase inhibitors in an in vitro assay. Anticancer Res. 1999 Mar-Apr;19(2A):1017-20. PubMed PMID: 10368648. 6: Johnston JO. Biological characterization of 10-(2-propynyl) estr-4-ene-3, 17-dione (MDL 18,962), an enzyme-activated inhibitor of aromatase. Steroids. 1987 Jul-Sep;50(1-3):105-20. PubMed PMID: 2847370. 7: Zimniski SJ, Brandt ME, Melner MH, Brodie AM, Puett D. Effect of 4-hydroxyandrostenedione on murine Leydig tumor cell steroidogenesis. Cancer Res. 1991 Jul 15;51(14):3663-8. PubMed PMID: 2065323. 8: Longcope C. Peripheral aromatization: studies on controlling factors. Steroids. 1987 Jul-Sep;50(1-3):253-67. PubMed PMID: 2847371. 9: Melby JC, Holbrook M, Griffing GT, Johnston JO. Antihypertensive effects of an aromatase inhibitor in the spontaneously hypertensive rat. Hypertension. 1987 Nov;10(5):484-7. PubMed PMID: 3666863. 10: Brodie AM. Aromatase, its inhibitors and their use in breast cancer treatment. Pharmacol Ther. 1993 Dec;60(3):501-15. Review. PubMed PMID: 8073072. 11: Zimniski SJ, Brandt ME, Melner MH, Covey DF, Puett D. Inhibition of Leydig tumor cell steroidogenesis by 10-propargylestr-4-ene-3,17-dione, an irreversible aromatase inhibitor. Cancer Res. 1985 Oct;45(10):4883-9. PubMed PMID: 4027975. 12: Doody KM, Murry BA, Mason JI. The use of rat Leydig tumor (R2C) and human hepatoma (HEPG2) cells to evaluate potential inhibitors of rat and human steroid aromatase. J Enzyme Inhib. 1990;4(2):153-8. PubMed PMID: 1965908. 13: di Salle E, Giudici D, Briatico G, Ornati G. Novel irreversible aromatase inhibitors. Ann N Y Acad Sci. 1990;595:357-67. PubMed PMID: 2375613. 14: Johnston JO, Wright CL, Metcalf BW. Biochemical and endocrine properties of a mechanism-based inhibitor of aromatase. Endocrinology. 1984 Aug;115(2):776-85. PubMed PMID: 6745181. 15: Brandt ME, Covey DF, Zimniski SJ. The effects of in vivo administration of 10-propargylestr-4-ene-3,17-dione on rat ovarian aromatase and estrogen levels. J Enzyme Inhib. 1990;4(2):143-52. PubMed PMID: 2098521. 16: Johnston JO, Wright CL, Leeson GA. Regioselectivity of metabolic activation of acetylenic steroids by hepatic cytochrome P450 isozymes. Steroids. 1991 Apr;56(4):180-4. PubMed PMID: 1871782. 17: Brandt ME, Puett D, Garola R, Fendl K, Covey DF, Zimniski SJ. Aromatase and aromatase inhibitors: from enzymology to selective chemotherapy. Prog Clin Biol Res. 1988;262:65-84. Review. PubMed PMID: 3287391. 18: Johnston JO, Wright CL, Shumaker RC. Human trophoblast xenografts in athymic mice: a model for peripheral aromatization. J Steroid Biochem. 1989 Oct;33(4A):521-9. PubMed PMID: 2811362. 19: Gomez-Sanchez EP, Gomez-Sanchez CE. The effect of gonadectomy and aromatase inhibition on the excretion of 19-nordeoxycorticosterone in rats. J Steroid Biochem Mol Biol. 1991 Aug;39(2):185-8. PubMed PMID: 1888677. 20: Kruter RH, Berkovitz GD, Migeon CJ, Brown TR. Effects of 10-(2-propynyl)-estr-4-ene-3,17-dione (MDL 18,962)--a mechanism-based irreversible inhibitor of aromatase--in cultured human foreskin fibroblasts. J Steroid Biochem. 1987 Aug;28(2):139-45. PubMed PMID: 3626551.