Pedunculoside | CAS#42719-32-4 | lipid-lowering

MedKoo Cat#: 585014 | Name: Pedunculoside

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pedunculoside, from leaves of Ilex chinensis, is a triterpene saponin that ameliorates high-fat diet induced hyperlipidemia in rats..

Chemical Structure

Pedunculoside

CAS#42719-32-4

Theoretical Analysis

MedKoo Cat#: 585014

Name: Pedunculoside

CAS#: 42719-32-4

Chemical Formula: C36H58O10

Exact Mass: 650.4030

Molecular Weight: 650.85

Elemental Analysis: C, 66.44; H, 8.98; O, 24.58

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Pedunculoside

IUPAC/Chemical Name

Urs-12-en-28-oic acid, 3,19,23-trihydroxy-, beta-D-glucopyranosyl ester, (3beta,4alpha)-

InChi Key

LARPFJIXBULVPK-FBAXZNBGSA-N

InChi Code

InChI=1S/C36H58O10/c1-19-9-14-36(30(43)46-29-27(42)26(41)25(40)21(17-37)45-29)16-15-33(4)20(28(36)35(19,6)44)7-8-23-31(2)12-11-24(39)32(3,18-38)22(31)10-13-34(23,33)5/h7,19,21-29,37-42,44H,8-18H2,1-6H3/t19-,21-,22-,23-,24+,25-,26+,27-,28-,29+,31+,32+,33-,34-,35-,36+/m1/s1

SMILES Code

C[C@@]1(CO)[C@@H](O)CC[C@]2(C)[C@@]3([H])CC=C4[C@]5([H])[C@](C)(O)[C@H](C)CC[C@@](C(O[C@H]6[C@@H]([C@H]([C@@H]([C@@H](CO)O6)O)O)O)=O)5CC[C@](C)4[C@@](C)3CC[C@@]12[H]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 650.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Zhao W, Pang L, Xu D, Zhang N. LC-MS/MS Determination and Pharmacokinetic Study of Pedunculoside in Rat Plasma after Oral Administration of Pedunculoside and Ilex rotunda Extract. Molecules. 2015 May 19;20(5):9084-98. doi: 10.3390/molecules20059084. PubMed PMID: 25996213; PubMed Central PMCID: PMC6272306. 2: Liu C, Shen YJ, Tu QB, Zhao YR, Guo H, Wang J, Zhang L, Shi HW, Sun Y. Pedunculoside, a novel triterpene saponin extracted from Ilex rotunda, ameliorates high-fat diet induced hyperlipidemia in rats. Biomed Pharmacother. 2018 May;101:608-616. doi: 10.1016/j.biopha.2018.02.131. Epub 2018 Mar 22. PubMed PMID: 29518607. 3: Liu C, Zhang W, Yang H, Sun W, Gong X, Zhao J, Sun Y, Diao G. A water-soluble inclusion complex of pedunculoside with the polymer β-cyclodextrin: a novel anti-inflammation agent with low toxicity. PLoS One. 2014 Jul 11;9(7):e101761. doi: 10.1371/journal.pone.0101761. eCollection 2014. PubMed PMID: 25013908; PubMed Central PMCID: PMC4094462. 4: Wang C, Chao Z, Sun W, Wu X, Ito Y. Enrichment and purification of pedunculoside and syringin from the barks of Ilex rotunda with macroporous resins. J Liq Chromatogr Relat Technol. 2014 Feb 1;37(4):572-587. PubMed PMID: 25104900; PubMed Central PMCID: PMC4120981. 5: Yang B, Li H, Ruan Q, Xuan S, Chen X, Cui H, Liu Z, Jin J, Zhao Z. Effects of Gut Microbiota and Ingredient-Ingredient Interaction on the Pharmacokinetic Properties of Rotundic Acid and Pedunculoside. Planta Med. 2019 Jul;85(9-10):729-737. doi: 10.1055/a-0902-5300. Epub 2019 Jun 5. PubMed PMID: 31167298. 6: Yang B, Li H, Ruan Q, Tong Y, Liu Z, Xuan S, Jin J, Zhao Z. Rapid profiling and pharmacokinetic studies of multiple potential bioactive triterpenoids in rat plasma using UPLC/Q-TOF-MS/MS after oral administration of Ilicis Rotundae Cortex extract. Fitoterapia. 2018 Sep;129:210-219. doi: 10.1016/j.fitote.2018.07.005. Epub 2018 Jul 5. PubMed PMID: 29981874. 7: Xie JB, Bi ZM, Li P. HPLC-ELSD determination of triterpenoids and triterpenoid saponins in Ilex pupurea leaves. Yao Xue Xue Bao. 2003 Jul;38(7):534-6. PubMed PMID: 14515801. 8: Chen G, Feng Y, Li X, Jiang Z, Bei B, Zhang L, Han Y, Li Y, Li N. Post-transcriptional Gene Regulation in Colitis Associated Cancer. Front Genet. 2019 Jun 19;10:585. doi: 10.3389/fgene.2019.00585. eCollection 2019. PubMed PMID: 31275360; PubMed Central PMCID: PMC6593052. 9: Wang C, Chao Z, Sun W, Wu X, Ito Y. ISOLATION OF GLYCOSIDES FROM THE BARKS OF ILEX ROTUNDA BY HIGH-SPEED COUNTER-CURRENT CHROMATOGRAPHY. J Liq Chromatogr Relat Technol. 2014 Apr 1;37(16):2363-2376. PubMed PMID: 25132792; PubMed Central PMCID: PMC4130163. 10: Zhao HR, Wang MS, Zhou GP. [Studies on constituents of Ilex chinensis Sims]. Zhongguo Zhong Yao Za Zhi. 1993 Apr;18(4):226-8, 255. Chinese. PubMed PMID: 8216789. 11: Zhou GS, Ma XL, Zeng KW, Tu PF, Jiang Y. Inhibitory activity of chemical constituents from Arenaria serpyllifolia on nitric oxide production. Planta Med. 2013 May;79(8):687-92. doi: 10.1055/s-0032-1328538. Epub 2013 May 13. PubMed PMID: 23670630. 12: Liao LP, Li SL, Li P. Simultaneous determination of seven triterpenoids and triterpenoid saponins in Folium llicis Purpureae by high performance liquid chromatography coupled with evaporative light scattering detection. J Sep Sci. 2005 Nov;28(16):2061-6. PubMed PMID: 16318200.