Fce 28260 | CAS#155651-56-2 | inhibitor

MedKoo Cat#: 585012 | Name: Fce 28260

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Fce 28260 is a 5 alpha-reductase inhibitor.

Chemical Structure

Fce 28260

CAS#155651-56-2

Theoretical Analysis

MedKoo Cat#: 585012

Name: Fce 28260

CAS#: 155651-56-2

Chemical Formula: C28H35F3N2O2

Exact Mass: 488.2651

Molecular Weight: 488.60

Elemental Analysis: C, 68.83; H, 7.22; F, 11.67; N, 5.73; O, 6.55

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Fce 28260; Fce28260; Fce-28260

IUPAC/Chemical Name

(22RS-N-1,1,1-Trifluoro-2-phenylprop-2-yl)-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxamide

InChi Key

FAIZUAWLKOHMOP-ZOIXLQFFSA-N

InChi Code

InChI=1S/C28H35F3N2O2/c1-25-15-13-20-18(9-12-22-26(20,2)16-14-23(34)32-22)19(25)10-11-21(25)24(35)33-27(3,28(29,30)31)17-7-5-4-6-8-17/h4-8,14,16,18-22H,9-13,15H2,1-3H3,(H,32,34)(H,33,35)/t18-,19-,20-,21+,22+,25-,26+,27?/m0/s1

SMILES Code

C[C@@]12[C@@H](C(NC(C)(C3=CC=CC=C3)C(F)(F)F)=O)CC[C@@]1([H])[C@]4([H])CC[C@@]5([H])NC(C=C[C@]5(C)[C@@]4([H])CC2)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 488.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Di Salle E, Briatico G, Giudici D, Ornati G, Zaccheo T, Buzzetti F, Nesi M, Panzeri A. Novel aromatase and 5 alpha-reductase inhibitors. J Steroid Biochem Mol Biol. 1994 Jun;49(4-6):289-94. PubMed PMID: 8043491. 2: Giudici D, Briatico G, Cominato C, Zaccheo T, Iehlè C, Nesi M, Panzeri A, di Salle E. FCE 28260, a new 5 alpha-reductase inhibitor: in vitro and in vivo effects. J Steroid Biochem Mol Biol. 1996 Jun;58(3):299-305. PubMed PMID: 8836165. 3: Rosen GJ, Wade J. The role of 5alpha-reductase activity in sexual behaviors of the green anole lizard. Physiol Behav. 2000 Jun 1-15;69(4-5):487-98. PubMed PMID: 10913788. 4: Zaccheo T, Giudici D, Panzeri A, di Salle E. Effect of the 5 alpha-reductase inhibitor PNU 156765, alone or in combination with flutamide, in the Dunning R3327 prostatic carcinoma model in rats. Chemotherapy. 1998 Jul-Aug;44(4):284-92. PubMed PMID: 9681205. 5: Dalla Valle L, Toffolo V, Vianello S, Belvedere P, Colombo L. Expression of cytochrome P450c17 and other steroid-converting enzymes in the rat kidney throughout the life-span. J Steroid Biochem Mol Biol. 2004 Jun;91(1-2):49-58. PubMed PMID: 15261307.