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MedKoo Cat#: 585011 | Name: U 37883A
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

U 37883A is a selective inhibitor of ATP-sensitive potassium (K_ATP) channels, particularly targeting vascular smooth muscle cells. By blocking these channels, it prevents potassium efflux, leading to membrane depolarization, calcium influx, and subsequent vasoconstriction. This pharmacological action makes it a valuable tool for studying vascular tone regulation and potential therapeutic applications in hypertension and cardiovascular disorders.

Chemical Structure

U 37883A
U 37883A
CAS#57568-80-6

Theoretical Analysis

MedKoo Cat#: 585011

Name: U 37883A

CAS#: 57568-80-6

Chemical Formula: C21H36ClN3O

Exact Mass: 381.2547

Molecular Weight: 381.99

Elemental Analysis: C, 66.03; H, 9.50; Cl, 9.28; N, 11.00; O, 4.19

Price and Availability

Size Price Availability Quantity
10mg USD 500.00 2 weeks
50mg USD 1,300.00 2 Weeks
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Related CAS #
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Synonym
U 37883A; U37883A; U-37883A; PNU 37883; PNU37883; PNU-37883
IUPAC/Chemical Name
4-Morpholinecarboximidamide, N-cyclohexyl-N'-tricyclo(3.3.1.1(3,7))dec-1-yl-, monohydrochloride
InChi Key
FZALCKUJYZCDOX-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H35N3O.ClH/c1-2-4-19(5-3-1)22-20(24-6-8-25-9-7-24)23-21-13-16-10-17(14-21)12-18(11-16)15-21;/h16-19H,1-15H2,(H,22,23);1H
SMILES Code
[H]Cl.N1(/C(NC2CCCCC2)=N\C3(C4)CC5CC4CC(C5)C3)CCOCC1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 381.99 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Turzo M, Vaith J, Lasitschka F, Weigand MA, Busch CJ. Role of ATP-sensitive potassium channels on hypoxic pulmonary vasoconstriction in endotoxemia. Respir Res. 2018 Feb 13;19(1):29. doi: 10.1186/s12931-018-0735-x. PMID: 29433570; PMCID: PMC5810061. 2: Yamamoto T, Takahara K, Inai T, Node K, Teramoto N. Molecular analysis of ATP-sensitive K(+) channel subunits expressed in mouse portal vein. Vascul Pharmacol. 2015 Dec;75:29-39. doi: 10.1016/j.vph.2015.06.018. Epub 2015 Jul 8. PMID: 26163942. 3: Kaye AD, Skonieczny BD, Kaye AJ, Harris ZI, Luk EJ. An Analysis of Responses to Defibrotide in the Pulmonary Vascular Bed of the Cat. Am J Ther. 2016 May- Jun;23(3):e757-65. doi: 10.1097/MJT.0000000000000010. PMID: 24368612. 4: Iwasa K, Zhu HL, Shibata A, Maehara Y, Teramoto N. Molecular analysis of ATP- sensitive K⁺ channel subunits expressed in mouse vas deferens myocytes. Br J Pharmacol. 2014 Jan;171(1):145-57. doi: 10.1111/bph.12437. PMID: 24117345; PMCID: PMC3874703. 5: Issa K, Kimmoun A, Collin S, Ganster F, Fremont-Orlowski S, Asfar P, Mertes PM, Levy B. Compared effects of inhibition and exogenous administration of hydrogen sulphide in ischaemia-reperfusion injury. Crit Care. 2013 Jul 10;17(4):R129. doi: 10.1186/cc12808. PMID: 23841996; PMCID: PMC4057116. 6: Suzuki Y, Inoue T, Murai M, Suzuki-Karasaki M, Ochiai T, Ra C. Depolarization potentiates TRAIL-induced apoptosis in human melanoma cells: role for ATP- sensitive K+ channels and endoplasmic reticulum stress. Int J Oncol. 2012 Aug;41(2):465-75. doi: 10.3892/ijo.2012.1483. Epub 2012 May 17. PMID: 22613960; PMCID: PMC3582902. 7: Hsu CY, Fang SY, Chen YZ, Roan JN, Chang SW, Huang CC, Liu YC, Lam CF, Tsai YC. Cardiovascular protection of activating KATP channel during ischemia- reperfusion acidosis. Shock. 2012 Jun;37(6):653-8. doi: 10.1097/SHK.0b013e318252caf6. PMID: 22552019. 8: Chan YL, Orie NN, Dyson A, Taylor V, Stidwill RP, Clapp LH, Singer M. Inhibition of vascular adenosine triphosphate-sensitive potassium channels by sympathetic tone during sepsis. Crit Care Med. 2012 Apr;40(4):1261-8. doi: 10.1097/CCM.0b013e31823da98d. PMID: 22425821. 9: Jolly L, March JE, Kemp PA, Bennett T, Gardiner SM. Mechanisms involved in the regional haemodynamic effects of intermedin (adrenomedullin 2) compared with adrenomedullin in conscious rats. Br J Pharmacol. 2009 Aug;157(8):1502-13. doi: 10.1111/j.1476-5381.2009.00306.x. PMID: 19681873; PMCID: PMC2765301. 10: Ploug KB, Sørensen MA, Strøbech L, Klaerke DA, Hay-Schmidt A, Sheykhzade M, Olesen J, Jansen-Olesen I. K ATP channels in pig and human intracranial arteries. Eur J Pharmacol. 2008 Dec 28;601(1-3):43-9. doi: 10.1016/j.ejphar.2008.10.041. Epub 2008 Oct 29. PMID: 18996111. 11: Ploug KB, Boni LJ, Baun M, Hay-Schmidt A, Olesen J, Jansen-Olesen I. K(ATP) channel expression and pharmacological in vivo and in vitro studies of the K(ATP) channel blocker PNU-37883A in rat middle meningeal arteries. Br J Pharmacol. 2008 May;154(1):72-81. doi: 10.1038/bjp.2008.86. Epub 2008 Mar 10. PMID: 18332850; PMCID: PMC2438990. 12: Nossaman BD, Bivalacqua TJ, Champion HC, Baber SR, Kadowitz PJ. Analysis of vasodilator responses to peroxynitrite in the hindlimb vascular bed of the cat. J Cardiovasc Pharmacol. 2007 Oct;50(4):358-66. doi: 10.1097/FJC.0b013e31811242cd. PMID: 18049302. 13: Jiang B, Wu L, Wang R. Sulphonylureas induced vasorelaxation of mouse arteries. Eur J Pharmacol. 2007 Dec 22;577(1-3):124-8. doi: 10.1016/j.ejphar.2007.09.007. Epub 2007 Sep 26. PMID: 17949709. 14: Tan JH, Al Abed A, Brock JA. Inhibition of KATP channels in the rat tail artery by neurally released noradrenaline acting on postjunctional alpha2-adrenoceptors. J Physiol. 2007 Jun 1;581(Pt 2):757-65. doi: 10.1113/jphysiol.2007.129536. Epub 2007 Mar 22. PMID: 17379634; PMCID: PMC2075182. 15: Teramoto N. Pharmacological Profile of U-37883A, a Channel Blocker of Smooth Muscle-Type ATP-Sensitive K Channels. Cardiovasc Drug Rev. 2006 Spring;24(1):25-32. doi: 10.1111/j.1527-3466.2006.00025.x. PMID: 16939631. 16: Tomoda T, Yunoki T, Naito S, Ito Y, Teramoto N. Multiple actions of U-37883A, an ATP-sensitive K+ channel blocker, on membrane currents in pig urethra. Eur J Pharmacol. 2005 Nov 7;524(1-3):1-10. doi: 10.1016/j.ejphar.2005.08.048. Epub 2005 Oct 19. PMID: 16242124. 17: Hanna ST, Cao K, Wang R. Interaction of acetylcholine with Kir6.1 channels heterologously expressed in human embryonic kidney cells. Eur J Pharmacol. 2005 May 16;515(1-3):34-42. doi: 10.1016/j.ejphar.2005.04.015. PMID: 15894309. 18: Teramoto N, Aishima M, Zhu HL, Tomoda T, Yunoki T, Takahashi-Yanaga F, Brading AF, Ito Y. Effects of U-37883A on intracellular Ca2+ -activated large- conductance K+ channels in pig proximal urethral myocytes. Eur J Pharmacol. 2004 Dec 3;506(1):1-7. doi: 10.1016/j.ejphar.2004.10.025. PMID: 15588618. 19: Rivo J, Zeira E, Galun E, Matot I. Activation of A3 adenosine receptors attenuates lung injury after in vivo reperfusion. Anesthesiology. 2004 Nov;101(5):1153-9. doi: 10.1097/00000542-200411000-00015. PMID: 15505451. 20: Kovalev H, Quayle JM, Kamishima T, Lodwick D. Molecular analysis of the subtype-selective inhibition of cloned KATP channels by PNU-37883A. Br J Pharmacol. 2004 Mar;141(5):867-73. doi: 10.1038/sj.bjp.0705670. Epub 2004 Feb 2. PMID: 14757705; PMCID: PMC1574259.

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