Synonym
ARN272; ARN-272; ARN 272;
IUPAC/Chemical Name
4-[[4-(4-hydroxyphenyl)-1-phthalazinyl]amino]-N-phenyl-benzamide
InChi Key
UPKNGUQNXSMHBE-UHFFFAOYSA-N
InChi Code
InChI=1S/C27H20N4O2/c32-22-16-12-18(13-17-22)25-23-8-4-5-9-24(23)26(31-30-25)28-21-14-10-19(11-15-21)27(33)29-20-6-2-1-3-7-20/h1-17,32H,(H,28,31)(H,29,33)
SMILES Code
O=C(NC1=CC=CC=C1)C2=CC=C(NC3=NN=C(C4=CC=C(O)C=C4)C5=C3C=CC=C5)C=C2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
432.48
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: O'Brien LD, Limebeer CL, Rock EM, Bottegoni G, Piomelli D, Parker LA.
Anandamide transport inhibition by ARN272 attenuates nausea-induced behaviour in
rats, and vomiting in shrews (Suncus murinus). Br J Pharmacol. 2013
Nov;170(5):1130-6. doi: 10.1111/bph.12360. PubMed PMID: 23991698; PubMed Central
PMCID: PMC3949659.
2: Fu J, Bottegoni G, Sasso O, Bertorelli R, Rocchia W, Masetti M, Guijarro A,
Lodola A, Armirotti A, Garau G, Bandiera T, Reggiani A, Mor M, Cavalli A,
Piomelli D. A catalytically silent FAAH-1 variant drives anandamide transport in
neurons. Nat Neurosci. 2011 Nov 20;15(1):64-9. doi: 10.1038/nn.2986. Erratum in:
Nat Neurosci. 2013 Dec;16(12):1907. PubMed PMID: 22101642; PubMed Central PMCID:
PMC3245783.
