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MedKoo Cat#: 581935 | Name: Sodium caprate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Sodium decanoate, or sodium caprate, is the sodium salt of caproic acid, a 10-carbon saturated fatty acid. It has amphiphilic character and can form micelles and liquid crystalline phases in aqueous solution. In a chemical model system, sodium caprate has been used in 13C NMR studies of the addition of hydrophilic and hydrophobic molecules to the 1-monooleoyl glycerol/water system, to elucidate the transport of biologically active molecules.

Chemical Structure

Sodium caprate
Sodium caprate
CAS#1002-62-6

Theoretical Analysis

MedKoo Cat#: 581935

Name: Sodium caprate

CAS#: 1002-62-6

Chemical Formula: C10H19NaO2

Exact Mass: 0.0000

Molecular Weight: 194.25

Elemental Analysis: C, 61.83; H, 9.86; Na, 11.84; O, 16.47

Price and Availability

Size Price Availability Quantity
5g USD 250.00 2 Weeks
25g USD 415.00 2 Weeks
50g USD 550.00 2 Weeks
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Related CAS #
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Synonym
Sodium caprate; Capric acid, sodium salt; Caprinic acid sodium salt; Decanoic acid, sodium salt; Sodium caprinate; Sodium decanoate; Sodium decanoic acid; Sodium-n-decanoate
IUPAC/Chemical Name
sodium decanoate
InChi Key
FIWQZURFGYXCEO-UHFFFAOYSA-M
InChi Code
InChI=1S/C10H20O2.Na/c1-2-3-4-5-6-7-8-9-10(11)12;/h2-9H2,1H3,(H,11,12);/q;+1/p-1
SMILES Code
C(CCCCCC)CCC(=O)[O-].[Na+]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, DMF, and ethanol
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Sodium caprate selectively reduces glutamate-induced currents in Xenopus oocytes expressing GluA2 and GluA3 subunit-containing AMPA receptors (IC50 = 0.52 mM) over those expressing GluA1 (IC50 = 2.09 mM) or GluA1 and GluA2 subunits (IC50 = 1.16 mM).
In vitro activity:
Sodium caprate has concentration-dependent anticancer effects on gastric cancer cells, inducing both apoptosis and necrosis. Sodium caprate induced apoptosis in gastric cancer cells at concentrations above 0.2 mM through the mitochondrial pathway. At 15 mM, sodium caprate caused necrosis by triggering cellular swelling and creating holes in the cell membrane. Levels of cAMP and ATP significantly decreased with 15 mM sodium caprate exposure. Reference: Hum Exp Toxicol. 2022 Jan-Dec;41:9603271221119182. https://pubmed.ncbi.nlm.nih.gov/36042573/
In vivo activity:
Sodium caprate boosted antioxidant capacity, intestinal morphology, and the gut barrier in intestinal cells, enhancing the growth performance of mice through GPR-43 signaling. It increased weight gain and ileal villus height compared to control and sodium butyrate treatment, along with raising α-diversity of ileal microbiota, volatile fatty acids concentration, and GPR-43 expression in the ileum and colon of mice. Reference: Nutrients. 2021 Aug 11;13(8):2756. https://pubmed.ncbi.nlm.nih.gov/34444916/
Solvent mg/mL mM comments
Solubility
DMF 5.0 25.74
DMSO 5.0 25.74
Ethanol 30.0 154.44
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 194.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Kim NH, Park JH, Koo DH, Lee T, Yang JY, Lee HY. Potential anticancer effect of sodium caprate on human gastric cancer cells. Hum Exp Toxicol. 2022 Jan-Dec;41:9603271221119182. doi: 10.1177/09603271221119182. PMID: 36042573. 2. Twarog C, Liu K, O'Brien PJ, Dawson KA, Fattal E, Illel B, Brayden DJ. A head-to-head Caco-2 assay comparison of the mechanisms of action of the intestinal permeation enhancers: SNAC and sodium caprate (C10). Eur J Pharm Biopharm. 2020 Jul;152:95-107. doi: 10.1016/j.ejpb.2020.04.023. Epub 2020 May 6. PMID: 32387703. 3. Zhao J, Hu J, Ma X. Sodium Decanoate Improves Intestinal Epithelial Barrier and Antioxidation via Activating G Protein-Coupled Receptor-43. Nutrients. 2021 Aug 11;13(8):2756. doi: 10.3390/nu13082756. PMID: 34444916; PMCID: PMC8401944. 4. Baluom M, Friedman M, Assaf P, Haj-Yehia AI, Rubinstein A. Synchronized release of sulpiride and sodium decanoate from HPMC matrices: a rational approach to enhance sulpiride absorption in the rat intestine. Pharm Res. 2000 Sep;17(9):1071-6. doi: 10.1023/a:1026449527891. PMID: 11087038.
In vitro protocol:
1. Kim NH, Park JH, Koo DH, Lee T, Yang JY, Lee HY. Potential anticancer effect of sodium caprate on human gastric cancer cells. Hum Exp Toxicol. 2022 Jan-Dec;41:9603271221119182. doi: 10.1177/09603271221119182. PMID: 36042573. 2. Twarog C, Liu K, O'Brien PJ, Dawson KA, Fattal E, Illel B, Brayden DJ. A head-to-head Caco-2 assay comparison of the mechanisms of action of the intestinal permeation enhancers: SNAC and sodium caprate (C10). Eur J Pharm Biopharm. 2020 Jul;152:95-107. doi: 10.1016/j.ejpb.2020.04.023. Epub 2020 May 6. PMID: 32387703.
In vivo protocol:
1. Zhao J, Hu J, Ma X. Sodium Decanoate Improves Intestinal Epithelial Barrier and Antioxidation via Activating G Protein-Coupled Receptor-43. Nutrients. 2021 Aug 11;13(8):2756. doi: 10.3390/nu13082756. PMID: 34444916; PMCID: PMC8401944. 2. Baluom M, Friedman M, Assaf P, Haj-Yehia AI, Rubinstein A. Synchronized release of sulpiride and sodium decanoate from HPMC matrices: a rational approach to enhance sulpiride absorption in the rat intestine. Pharm Res. 2000 Sep;17(9):1071-6. doi: 10.1023/a:1026449527891. PMID: 11087038.
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PKF 115-584

PKF 115-584