MedKoo Cat#: 573703 | Name: Nitrefazole
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Nitrefazole is a nitroimidazole derivative with the ability to inhibit aldehyde dehydrogenase. This enzyme crucial to the metabolism of alcohol and is suitable for aldehyde dehydrogenase (ALDH) related research.

Chemical Structure

Nitrefazole
CAS#21721-92-6

Theoretical Analysis

MedKoo Cat#: 573703

Name: Nitrefazole

CAS#: 21721-92-6

Chemical Formula: C10H8N4O4

Exact Mass: 248.0546

Molecular Weight: 248.20

Elemental Analysis: C, 48.39; H, 3.25; N, 22.57; O, 25.78

Price and Availability

Size Price Availability Quantity
250mg USD 325.00
2g USD 1,575.00
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Related CAS #
No Data
Synonym
Altimol, BT-985, EMD 15 700, EMD 15700, EMD-15,700; Nitrefazol, Nitrefazole, Nitrefazolum
IUPAC/Chemical Name
1H-Imidazole, 2-methyl-4-nitro-1-(4-nitrophenyl)- (9CI)
InChi Key
NMTBSNPBIGRZBL-UHFFFAOYSA-N
InChi Code
1S/C10H8N4O4/c1-7-11-10(14(17)18)6-12(7)8-2-4-9(5-3-8)13(15)16/h2-6H,1H3
SMILES Code
Cc1nc(cn1c2ccc(cc2)[N+](=O)[O-])[N+](=O)[O-]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Biological target:
Nitrefazole is a 4-nitroimidazole derivative with strong and long lasting inhibition of aldehyde dehydrogenase (ALDH), an enzyme involved in the metabolism of alcohol.
In vitro activity:
TBD
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 248.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
1: Suokas A, Kupari M, Pettersson J, Lindros K. The nitrefazole-ethanol interaction in man: cardiovascular responses and the accumulation of acetaldehyde and catecholamines. Alcohol Clin Exp Res. 1985 May-Jun;9(3):221-7. PubMed PMID: 3893193. 2: Stockwell T, Sutherland G, Edwards G. The impact of a new alcohol sensitizing agent (nitrefazole) on craving in severely dependent alcoholics. Br J Addict. 1984 Dec;79(4):403-9. PubMed PMID: 6598964.