MedKoo Cat#: 565427 | Name: LQZ-7F

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LQZ-7F is an inhibitor of the dimerization of the oncoprotein survivin, being survivin degradation, mitotic arrest, and apoptosis, and blocking the growth of human tumors in mouse xenograft assays.

Chemical Structure

LQZ-7F
LQZ-7F
CAS#1044664-73-4

Theoretical Analysis

MedKoo Cat#: 565427

Name: LQZ-7F

CAS#: 1044664-73-4

Chemical Formula: C24H19N7O4

Exact Mass: 469.1499

Molecular Weight: 469.46

Elemental Analysis: C, 61.40; H, 4.08; N, 20.89; O, 13.63

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
LQZ7F; LQZ 7F; LQZ-7F
IUPAC/Chemical Name
3-(5-((2-(6-((2,3-Dimethylphenyl)amino)-[1,2,5]oxadiazolo[3,4-b]pyrazin-5-yl)hydrazineylidene)methyl)furan-2-yl)benzoic acid
InChi Key
ONXLPQBYPUBYEJ-BRJLIKDPSA-N
InChi Code
InChI=1S/C24H19N7O4/c1-13-5-3-8-18(14(13)2)26-20-21(28-23-22(27-20)30-35-31-23)29-25-12-17-9-10-19(34-17)15-6-4-7-16(11-15)24(32)33/h3-12H,1-2H3,(H,32,33)(H,26,27,30)(H,28,29,31)/b25-12+
SMILES Code
O=C(O)C1=CC=CC(C2=CC=C(/C=N/NC3=NC4=NON=C4N=C3NC5=CC=CC(C)=C5C)O2)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 469.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Qi J, Dong Z, Liu J, Peery RC, Zhang S, Liu JY, Zhang JT. Effective Targeting of the Survivin Dimerization Interface with Small-Molecule Inhibitors. Cancer Res. 2016 Jan 15;76(2):453-62. doi: 10.1158/0008-5472.CAN-15-1874. Epub 2016 Jan 7. Erratum in: Cancer Res. 2018 Dec 15;78(24):6904. PubMed PMID: 26744521.