SNIPER(CRABP)-11 | SN-11 | CAS#1384275-50-6

MedKoo Cat#: 555560 | Name: SNIPER(CRABP)-11

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SNIPER(CRABP)-11, also known as PROTAC cIAP1 degrader-4, is a potent protein degrader. SNIPER(CRABP)-11 displayed degradation activity toward the mitochondrial CRABP-II protein.

Chemical Structure

SNIPER(CRABP)-11

CAS#1384275-50-6

Theoretical Analysis

MedKoo Cat#: 555560

Name: SNIPER(CRABP)-11

CAS#: 1384275-50-6

Chemical Formula: C60H83N7O10

Exact Mass: 1061.6201

Molecular Weight: 1062.36

Elemental Analysis: C, 67.84; H, 7.88; N, 9.23; O, 15.06

Price and Availability

Size	Price	Availability
1mg	USD 190.00	Ready to ship
5mg	USD 450.00	Ready to ship
10mg	USD 750.00	Ready to ship
25mg	USD 1,250.00	Ready to ship
50mg	USD 1,950.00	Ready to ship
100mg	USD 2,950.00	Ready to ship

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

No Data

Synonym

SNIPER(CRABP)-11; SNIPER(CRABP)11; SNIPER(CRABP) 11; SN-11; SN 11; SN11; PROTAC cIAP1 degrader-4,

IUPAC/Chemical Name

(2E,4E,6E,8E)-9-((E)-3-((((S)-3-benzhydryl-1-((S)-1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidin-2-yl)-1,4,15-trioxo-8,11-dioxa-2,5,14-triazahexadecan-16-yl)oxy)imino)-2,6,6-trimethylcyclohex-1-en-1-yl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid

InChi Key

JKPIDKPKBOTXBU-HMLGKSOISA-N

InChi Code

InChI=1S/C60H83N7O10/c1-41(19-17-20-42(2)39-52(69)70)28-29-48-43(3)49(30-31-60(48,5)6)66-77-40-51(68)62-32-35-75-37-38-76-36-33-63-58(73)55(53(45-21-11-8-12-22-45)46-23-13-9-14-24-46)65-57(72)50-27-18-34-67(50)59(74)54(47-25-15-10-16-26-47)64-56(71)44(4)61-7/h8-9,11-14,17,19-24,28-29,39,44,47,50,53-55,61H,10,15-16,18,25-27,30-38,40H2,1-7H3,(H,62,68)(H,63,73)(H,64,71)(H,65,72)(H,69,70)/b20-17+,29-28+,41-19+,42-39+,66-49+/t44-,50-,54-,55-/m0/s1

SMILES Code

CC(/C(CCC(C)1C)=N/OCC(NCCOCCOCCNC([C@H](C(C2=CC=CC=C2)C3=CC=CC=C3)NC([C@@H]4CCCN4C([C@H](C5CCCCC5)NC([C@H](C)NC)=O)=O)=O)=O)=O)=C1/C=C/C(C)=C/C=C/C(C)=C/C(O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Certificate of Analysis

View CoA: current batch, Lot# YXM200214

QC Data

View QC data: current batch, Lot# YXM200214

Safety Data Sheet (SDS)

View Safety Data Sheet (SDS)

Instruction

View handling instruction

Biological target:

SNIPER(CRABP)-11 had degradation activity toward the mitochondrial CRABP-II protein.

In vitro activity:

This study highlighted SNIPER molecules’ ability to target proteins in different cellular compartments. Different SNIPER(CRABP) variants were tested, but SNIPER(CRABP)-11 demonstrated degradation activity specifically for the mitochondrial CRABP-II protein. The E3 ligase responsible for degradation varied depending on the CRABP-II protein's localization. Reference: Mol Pharmacol. 2017 Mar;91(3):159-166. https://pubmed.ncbi.nlm.nih.gov/27965304/

In vivo activity:

To be determined

Preparing Stock Solutions

The following data is based on the product molecular weight 1,062.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Okuhira K, Shoda T, Omura R, Ohoka N, Hattori T, Shibata N, Demizu Y, Sugihara R, Ichino A, Kawahara H, Itoh Y, Ishikawa M, Hashimoto Y, Kurihara M, Itoh S, Saito H, Naito M. Targeted Degradation of Proteins Localized in Subcellular Compartments by Hybrid Small Molecules. Mol Pharmacol. 2017 Mar;91(3):159-166. doi: 10.1124/mol.116.105569. Epub 2016 Dec 13. PMID: 27965304.

In vitro protocol:

In vivo protocol:

To be determined

1: Okuhira K, Shoda T, Omura R, et al. Targeted Degradation of Proteins Localized in Subcellular Compartments by Hybrid Small Molecules. Mol Pharmacol. 2017;91(3):159–166. doi:10.1124/mol.116.105569 2: Yamano, K., & Youle, R. J. (2020). Two different axes CALCOCO2-RB1CC1 and OPTN-ATG9A initiate PRKN-mediated mitophagy. Autophagy, 16(11), 2105-2107.