MedKoo Cat#: 565418 | Name: SKLB-329

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SKLB-329 is a multikinase inhibitor which potently inhibits angiogenesis-related kinases including VEGFR1/2/3, FGFR2, and the Src kinase. SKLB-329 was preclinically evaluated as a therapeutic agent against hepatocellular carcinoma.

Chemical Structure

SKLB-329
SKLB-329
CAS#NONE

Theoretical Analysis

MedKoo Cat#: 565418

Name: SKLB-329

CAS#: NONE

Chemical Formula: C19H11ClF4N6O2

Exact Mass: 466.0568

Molecular Weight: 466.78

Elemental Analysis: C, 48.89; H, 2.38; Cl, 7.59; F, 16.28; N, 18.00; O, 6.86

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
SKLB-329; SKLB 329; SKLB329
IUPAC/Chemical Name
1-(4-((1H-Pyrazolo[3,4-d]pyrimidin-4-yl)oxy)-2-fluorophenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea
InChi Key
NSYMATNYFQDESU-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H11ClF4N6O2/c20-13-3-1-9(5-12(13)19(22,23)24)28-18(31)29-15-4-2-10(6-14(15)21)32-17-11-7-27-30-16(11)25-8-26-17/h1-8H,(H2,28,29,31)(H,25,26,27,30)
SMILES Code
O=C(NC1=CC=C(Cl)C(C(F)(F)F)=C1)NC2=CC=C(OC3=C4C(NN=C4)=NC=N3)C=C2F
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 466.78 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhong L, Fu XY, Zou C, Yang LL, Zhou S, Yang J, Tang Y, Cheng C, Li LL, Xiang R, Chen LJ, Chen YZ, Wei YQ, Yang SY. A preclinical evaluation of a novel multikinase inhibitor, SKLB-329, as a therapeutic agent against hepatocellular carcinoma. Int J Cancer. 2014 Dec 15;135(12):2972-83. doi: 10.1002/ijc.28944. Epub 2014 May 12. PubMed PMID: 24789676.