Synonym
TXA-1 Hydrochloride; TXA 1 Hydrochloride; TXA1 Hydrochloride; TXA-1 HCl; TXA 1 HCl; TXA1 HCl
IUPAC/Chemical Name
1-{[2-(Diethylamino)ethyl]amino}-4-propoxy-9H- thioxanthen-9-one Hydrochloride
InChi Key
NFELQYYDCARVPN-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H28N2O2S.ClH/c1-4-15-26-18-12-11-17(23-13-14-24(5-2)6-3)20-21(25)16-9-7-8-10-19(16)27-22(18)20;/h7-12,23H,4-6,13-15H2,1-3H3;1H
SMILES Code
O=C1C2=C(SC3=C1C=CC=C3)C(OCCC)=CC=C2NCCN(CC)CC.[H]Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
421.00
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Lima RT, Sousa D, Gomes AS, Mendes N, Matthiesen R, Pedro M, Marques F, Pinto MM, Sousa E, Vasconcelos MH. The Antitumor Activity of a Lead Thioxanthone is Associated with Alterations in Cholesterol Localization. Molecules. 2018 Dec 12;23(12). pii: E3301. doi: 10.3390/molecules23123301. PubMed PMID: 30545153; PubMed Central PMCID: PMC6321308.
2: Barbosa J, Lima RT, Sousa D, Gomes AS, Palmeira A, Seca H, Choosang K, Pakkong P, Bousbaa H, Pinto MM, Sousa E, Vasconcelos MH, Pedro M. Screening a Small Library of Xanthones for Antitumor Activity and Identification of a Hit Compound which Induces Apoptosis. Molecules. 2016 Jan 13;21(1):81. doi: 10.3390/molecules21010081. PubMed PMID: 26771595; PubMed Central PMCID: PMC6274047.
