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MedKoo Cat#: 565398 | Name: LP-925219

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LP-925219 is an inhibitor of both renal SGLT1 and SGLT2.

Chemical Structure

LP-925219
LP-925219
CAS#NONE

Theoretical Analysis

MedKoo Cat#: 565398

Name: LP-925219

CAS#: NONE

Chemical Formula: C20H23ClO5S

Exact Mass: 410.0955

Molecular Weight: 410.91

Elemental Analysis: C, 58.46; H, 5.64; Cl, 8.63; O, 19.47; S, 7.80

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
LP925219; LP 925219; LP-925219
IUPAC/Chemical Name
(2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-methoxybenzyl)phenyl)-6-(methylthio)tetrahydro-2H-pyran-3,4,5-triol
InChi Key
LRAPPBHMSJGTEO-SWBPCFCJSA-N
InChi Code
InChI=1S/C20H23ClO5S/c1-25-14-6-3-11(4-7-14)9-13-10-12(5-8-15(13)21)19-17(23)16(22)18(24)20(26-19)27-2/h3-8,10,16-20,22-24H,9H2,1-2H3/t16-,17-,18+,19+,20-/m1/s1
SMILES Code
O[C@H]1[C@H](C2=CC=C(Cl)C(CC3=CC=C(OC)C=C3)=C2)O[C@H](SC)[C@@H](O)[C@@H]1O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 410.91 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Powell DR, Smith MG, Doree DD, Harris AL, Xiong WW, Mseeh F, Wilson A, Gopinathan S, Diaz D, Goodwin NC, Harrison B, Strobel E, Rawlins DB, Carson K, Zambrowicz B, Ding ZM. LP-925219 maximizes urinary glucose excretion in mice by inhibiting both renal SGLT1 and SGLT2. Pharmacol Res Perspect. 2015 Mar;3(2):e00129. doi: 10.1002/prp2.129. Epub 2015 Mar 31. PubMed PMID: 26038705; PubMed Central PMCID: PMC4448982.