MedKoo Cat#: 565395 | Name: BC-1485

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BC-1485 is a first-in-class inhibitor of Fibrosis-inducing E3 ligase 1 (FIEL1 ), which disrupts FIEL1-directed PIAS4 ubiquitination.

Chemical Structure

BC-1485
BC-1485
CAS#2035085-19-7

Theoretical Analysis

MedKoo Cat#: 565395

Name: BC-1485

CAS#: 2035085-19-7

Chemical Formula: C19H21N5O5S

Exact Mass: 431.1263

Molecular Weight: 431.47

Elemental Analysis: C, 52.89; H, 4.91; N, 16.23; O, 18.54; S, 7.43

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Synonym
BC1485; BC 1485; BC-1485
IUPAC/Chemical Name
N-(1-(Dimethylamino)-1-oxopropan-2-yl)-4-((2-oxo-2,3-dihydro-1H-benzo[d]imidazole)-5-sulfonamido)benzamide
InChi Key
ZDIJTGCDKBHHPD-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H21N5O5S/c1-11(18(26)24(2)3)20-17(25)12-4-6-13(7-5-12)23-30(28,29)14-8-9-15-16(10-14)22-19(27)21-15/h4-11,23H,1-3H3,(H,20,25)(H2,21,22,27)
SMILES Code
O=C(NC(C)C(N(C)C)=O)C1=CC=C(NS(=O)(C2=CC=C(C(N3)=C2)NC3=O)=O)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 431.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Lear T, Chen BB. Therapeutic targets in fibrotic pathways. Cytokine. 2016 Dec;88:193-195. doi: 10.1016/j.cyto.2016.09.008. Epub 2016 Sep 19. PubMed PMID: 27658114; PubMed Central PMCID: PMC5119757.