MedKoo Cat#: 565392 | Name: PCSK9-IN-4d

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PCSK9-IN-4d is a PCSK9 mRNA translation inhibitor.

Chemical Structure

PCSK9-IN-4d
PCSK9-IN-4d
CAS#NONE

Theoretical Analysis

MedKoo Cat#: 565392

Name: PCSK9-IN-4d

CAS#: NONE

Chemical Formula: C22H29N5O

Exact Mass: 379.2372

Molecular Weight: 379.51

Elemental Analysis: C, 69.63; H, 7.70; N, 18.45; O, 4.22

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
PCSK9-IN-4d; PCSK9 IN-4d; PCSK9-IN 4d
IUPAC/Chemical Name
(R)-N-(3-Methylpyrazin-2-yl)-4-phenyl-N-(piperidin-3-yl)piperidine-1-carboxamide
InChi Key
UQVPGVALXWIBAG-HXUWFJFHSA-N
InChi Code
InChI=1S/C22H29N5O/c1-17-21(25-13-12-24-17)27(20-8-5-11-23-16-20)22(28)26-14-9-19(10-15-26)18-6-3-2-4-7-18/h2-4,6-7,12-13,19-20,23H,5,8-11,14-16H2,1H3/t20-/m1/s1
SMILES Code
O=C(N1CCC(C2=CC=CC=C2)CC1)N(C3=NC=CN=C3C)[C@H]4CNCCC4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 379.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Dressel A, Schmidt B, Schmidt N, Laufs U, Fath F, Chapman MJ, Grammer TB, März W. Cost effectiveness of lifelong therapy with PCSK9 inhibitors for lowering cardiovascular events in patients with stable coronary artery disease: Insights from the Ludwigshafen Risk and Cardiovascular Health cohort. Vascul Pharmacol. 2019 Jun 14:106566. doi: 10.1016/j.vph.2019.106566. [Epub ahead of print] PubMed PMID: 31207358.