MedKoo Cat#: 408015 | Name: MUN21754
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

MUN21754, also known as JAK/HDAC-IN-1, is a potent and selective dual JAK2/HDAC inhibitor, MUN21754 exhibits antiproliferative and proapoptotic activities in several hematological cell lines. MUN21754 has CAS#2284621-75-4 and inchi key MTOQNLGMTJOJOF-UHFFFAOYSA-N. This product has no formal name. For the convenience of communication, we name it MUN21754. The 3 letters from its inch key and last 5 digit CAS# was used for name.

Chemical Structure

MUN21754
MUN21754
CAS#2284621-75-4

Theoretical Analysis

MedKoo Cat#: 408015

Name: MUN21754

CAS#: 2284621-75-4

Chemical Formula: C19H21Cl2N7O2

Exact Mass: 449.1134

Molecular Weight: 450.32

Elemental Analysis: C, 50.68; H, 4.70; Cl, 15.74; N, 21.77; O, 7.11

Price and Availability

Size Price Availability Quantity
1g USD 4,250.00
2g USD 7,450.00
5g USD 14,650.00
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Related CAS #
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Synonym
JAK/HDAC-IN-1; MUN21754; MUN-21754; MUN 21754;
IUPAC/Chemical Name
6-(4-((5-chloro-4-((4-chlorophenyl)amino)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)-N-hydroxyhexanamide
InChi Key
MTOQNLGMTJOJOF-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H21Cl2N7O2/c20-13-5-7-14(8-6-13)24-18-16(21)11-22-19(26-18)25-15-10-23-28(12-15)9-3-1-2-4-17(29)27-30/h5-8,10-12,30H,1-4,9H2,(H,27,29)(H2,22,24,25,26)
SMILES Code
O=C(NO)CCCCCN1N=CC(NC2=NC=C(Cl)C(NC3=CC=C(Cl)C=C3)=N2)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 450.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Liang X, et al. Discovery of Novel Janus Kinase (JAK) and Histone Deacetylase (HDAC) Dual Inhibitors for the Treatment of Hematological Malignancies. J Med Chem. 2019 Apr 25;62(8):3898-3923.