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MedKoo Cat#: 565378 | Name: JSI287

Description:

WARNING: This product is for research use only, not for human or veterinary use.

JSI287 is a ERK inhibitor, alleviating IMQ-induced mice skin lesions through ERK/IL-17 signaling pathway

Chemical Structure

JSI287
JSI287
CAS#NONE

Theoretical Analysis

MedKoo Cat#: 565378

Name: JSI287

CAS#: NONE

Chemical Formula: C26H22Cl2FN5O2

Exact Mass: 525.1135

Molecular Weight: 526.39

Elemental Analysis: C, 59.33; H, 4.21; Cl, 13.47; F, 3.61; N, 13.30; O, 6.08

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
JSI-287; JSI 287; JSI287
IUPAC/Chemical Name
(S)-7-(2-((2-chloro-4-fluorophenyl)amino)-5-methylpyrimidin-4-yl)-2-(1-(3-chlorophenyl)-2-hydroxyethyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one
InChi Key
JHGJUQUMQAHXRV-HSZRJFAPSA-N
InChi Code
InChI=1S/C26H22Cl2FN5O2/c1-15-12-30-26(31-21-6-5-19(29)11-20(21)28)32-24(15)17-10-22-25(36)34(8-7-33(22)13-17)23(14-35)16-3-2-4-18(27)9-16/h2-6,9-13,23,35H,7-8,14H2,1H3,(H,30,31,32)/t23-/m1/s1
SMILES Code
O=C1C2=CC(C3=NC(NC4=CC=C(F)C=C4Cl)=NC=C3C)=CN2CCN1[C@@H](C5=CC=CC(Cl)=C5)CO
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 526.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Huang X, Yu P, Liu M, Deng Y, Dong Y, Liu Q, Zhang J, Wu T. ERK inhibitor JSI287 alleviates imiquimod-induced mice skin lesions by ERK/IL-17 signaling pathway. Int Immunopharmacol. 2019 Jan;66:236-241. doi: 10.1016/j.intimp.2018.11.031. Epub 2018 Nov 24. PubMed PMID: 30481683.

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KRN7000

KRN7000

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