Synonym
Bisazir; AI3-61585
IUPAC/Chemical Name
Phosphinothioic amide, P,P-bis(1-aziridinyl)-N-methyl-
InChi Key
NZPKARLAFLAVLO-UHFFFAOYSA-N
InChi Code
InChI=1S/C5H12N3PS/c1-6-9(10,7-2-3-7)8-4-5-8/h2-5H2,1H3,(H,6,10)
SMILES Code
S=P(N1CC1)(N2CC2)NC
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
177.21
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Srivastava VK, Kumar K. Effect of the chemosterilant bisazir on the eggs of Earias fabia stoll. Toxicol Lett. 1984 Nov;23(2):195-200. PubMed PMID: 6209825.
2: Sucharit S, Kerdpibule V, Chomcharn Y, Limsuwan S. Plasmodium falciparum infection in Bisazir chemosterilized Anopheles dirus in laboratory studies. Southeast Asian J Trop Med Public Health. 1984 Jun;15(2):228-33. PubMed PMID: 6390705.
3: Ciereszko A, Wolfe TD, Dabrowski K. Analysis of DNA damage in sea lamprey (Petromyzon marinus) spermatozoa by UV, hydrogen peroxide, and the toxicant bisazir. Aquat Toxicol. 2005 Jun 15;73(2):128-38. PubMed PMID: 15885821.
4: Srivastava VK, Kumar K. Effect of the chemosterilant bisazir on the testes of the spotted bollworm Earias fabia stoll. Toxicology. 1984 Jun;31(3-4):335-42. PubMed PMID: 6740707.
5: Easton ER, Catangui MA. Vinyl plastic cage design for single-mating experiments to chemosterilize the stable fly (Diptera: Muscidae) with bisazir. J Econ Entomol. 1988 Feb;81(1):400-2. PubMed PMID: 3351084.
6: Mishra RK, Jha LK, Crystal MM. Histopathological effects of bisazir and triphenyl tin chloride on the ovary of Periplaneta americana (Blattaria: Blattidae). J Invertebr Pathol. 1984 Nov;44(3):349-50. PubMed PMID: 6501921.
7: Zakharova NF. [Evaluation of bisazir used as a chemosterilant of mosquitoes]. Med Parazitol (Mosk). 1983 Jan-Feb;52(1):42-6. Russian. PubMed PMID: 6843495.
8: Zakharova NF. [Comparative evaluation of the effect of bisazir and thiophosphamide sterilization on the sexual activity of male mosquitoes]. Med Parazitol (Mosk). 1983 Jul-Aug;(4):38-42. Russian. PubMed PMID: 6415380.
9: Ciereszko A, Babiak I, Dabrowski K. Efficacy of animal anti-fertility compounds against sea lamprey (Petromyzon marinus) spermatozoa. Theriogenology. 2004 Apr 15;61(6):1039-50. PubMed PMID: 15036993.
10: Hall MJ, Langley PA. Development of a system for sterilizing tsetse flies, Glossina spp., in the field. Med Vet Entomol. 1987 Apr;1(2):201-10. PubMed PMID: 2979533.
11: Grover KK, Agarwal HV. Feasibility of using sterile-male technique for the control of Anopheles stephensi Liston in the field: laboratory & field cage studies with chemosterilants. Indian J Exp Biol. 1980 Jun;18(6):615-9. PubMed PMID: 6777293.
12: El-Gazzar LM, Dame DA. Effects of combinations of irradiation and chemosterilization on mating competitiveness of Culex quinquefasciatus Say. J Econ Entomol. 1983 Dec;76(6):1331-4. PubMed PMID: 6662984.
