CHDI-390576 is a potent, cell permeable and CNS penetrant class IIa histone deacetylase (HDAC) inhibitor. Dose escalation pharmacokinetic analysis demonstrated that upon oral administration, CHDI-390576 can reach exposure levels in mouse plasma, muscle and brain in excess of cellular class IIa HDAC IC50 levels for ∼8 h. Given the interest in aberrant class IIa HDAC function for a number of neurodegenerative, neuromuscular, cardiac and oncology indications, CHDI-390576 provides a selective and potent compound to query the role of class IIa HDAC biology, and the impact of class IIa catalytic site occupancy in vitro and in vivo.
MedKoo Cat#: 565361
Name: CHDI-390576
CAS#: 1629729-98-1
Chemical Formula: C19H13F4N3O2
Exact Mass: 391.0944
Molecular Weight: 391.33
Elemental Analysis: C, 58.32; H, 3.35; F, 19.42; N, 10.74; O, 8.18
The following data is based on the product molecular weight 391.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
