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MedKoo Cat#: 573638 | Name: AL-6598
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

AL-6598 is a DP prostaglandin receptor agonist which may lead to sustained intraocular pressure reduction. This bioactivity may be useful in the treatment of glaucoma.

Chemical Structure

AL-6598
CAS#170291-06-2

Theoretical Analysis

MedKoo Cat#: 573638

Name: AL-6598

CAS#: 170291-06-2

Chemical Formula: C23H39ClO5

Exact Mass: 430.2486

Molecular Weight: 431.01

Elemental Analysis: C, 64.09; H, 9.12; Cl, 8.22; O, 18.56

Price and Availability

Size Price Availability Quantity
1mg USD 500.00 2 Weeks
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Related CAS #
No Data
Synonym
AL-6598, AL6598, AL 6598
IUPAC/Chemical Name
Acetic acid, (((2Z)-4-((1R,2R,3R,5R)-5-chloro-2-((3R)-3-cyclohexyl-3-hydroxypropyl)-3-hydroxycyclopentyl)-2-butenyl)oxy)-, 1-methylethyl ester
InChi Key
GXLUEHGRKZQLOO-QMAHXAMHSA-N
InChi Code
1S/C23H39ClO5/c1-16(2)29-23(27)15-28-13-7-6-10-18-19(22(26)14-20(18)24)11-12-21(25)17-8-4-3-5-9-17/h6-7,16-22,25-26H,3-5,8-15H2,1-2H3/b7-6-/t18-,19-,20-,21-,22-/m1/s1
SMILES Code
CC(C)OC(=O)COC\C=C/C[C@H]1[C@H](Cl)C[C@@H](O)[C@@H]1CC[C@@H](O)C2CCCCC2
Appearance
A solution in methyl acetate
Purity
97% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 431.01 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sharif NA, Williams GW, Crider JY, Xu SX, Davis TL. Molecular pharmacology of the DP/EP2 class prostaglandin AL-6598 and quantitative autoradiographic visualization of DP and EP2 receptor sites in human eyes. J Ocul Pharmacol Ther. 2004 Dec;20(6):489-508. doi: 10.1089/jop.2004.20.489. PMID: 15684809. 2: Toris CB, Zhan GL, Feilmeier MR, Camras CB, McLaughlin MA. Effects of a prostaglandin DP receptor agonist, AL-6598, on aqueous humor dynamics in a nonhuman primate model of glaucoma. J Ocul Pharmacol Ther. 2006 Apr;22(2):86-92. doi: 10.1089/jop.2006.22.86. PMID: 16722794. 3: Hellberg MR, McLaughlin MA, Sharif NA, DeSantis L, Dean TR, Kyba EP, Bishop JE, Klimko PG, Zinke PW, Selliah RD, Barnes G, DeFaller J, Kothe A, Landry T, Sullivan EK, Andrew R, Davis AA, Silver L, Bergamini MV, Robertson S, Weiner AL, Sallee VL. Identification and characterization of the ocular hypotensive efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist, and AL-6598, a DP prostaglandin receptor agonist. Surv Ophthalmol. 2002 Aug;47 Suppl 1:S13-33. doi: 10.1016/s0039-6257(02)00293-x. PMID: 12204698. 4: Hellberg MR, Conrow RE, Sharif NA, McLaughlin MA, Bishop JE, Crider JY, Dean WD, DeWolf KA, Pierce DR, Sallee VL, Selliah RD, Severns BS, Sproull SJ, Williams GW, Zinke PW, Klimko PG. 3-Oxa-15-cyclohexyl prostaglandin DP receptor agonists as topical antiglaucoma agents. Bioorg Med Chem. 2002 Jun;10(6):2031-49. doi: 10.1016/s0968-0896(02)00016-0. PMID: 11937363. 5: Sharif NA. Identifying new drugs and targets to treat rapidly elevated intraocular pressure for angle closure and secondary glaucomas to curb visual impairment. Exp Eye Res. 2023 Mar 21:109444. doi: 10.1016/j.exer.2023.109444. Epub ahead of print. PMID: 36958427. 6: Sharif NA, Davis TL, Williams GW. Ocular hypotensive DP-class prostaglandin receptor affinities determined by quantitative autoradiography on human eye sections. J Ocul Pharmacol Ther. 2005 Apr;21(2):121-32. doi: 10.1089/jop.2005.21.121. PMID: 15857278.