CWHM-1552 is a potent and orally active Antimalarial agent. CWHM-1552 has an in vitro IC50 of 51 nM in the P. falciparum 3D7 assay and an in vivo ED90 of <10 mg/kg/day and ED99 of 30 mg/kg/day in a murine P. chabaudi mode. CWHM-1552 has modest affinities for the hERG channel and inhibit CYP 3A4.
MedKoo Cat#: 555552
Name: CWHM-1552
CAS#: Unknown
Chemical Formula: C22H27F2N3O
Exact Mass: 387.2122
Molecular Weight: 387.47
Elemental Analysis: C, 68.20; H, 7.02; F, 9.81; N, 10.84; O, 4.13
The following data is based on the product molecular weight 387.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
