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MedKoo Cat#: 584956 | Name: Org 2058

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Org 2058 is a synthetic progestin.

Chemical Structure

Org 2058
Org 2058
CAS#24320-06-7

Theoretical Analysis

MedKoo Cat#: 584956

Name: Org 2058

CAS#: 24320-06-7

Chemical Formula: C22H32O3

Exact Mass: 344.2351

Molecular Weight: 344.50

Elemental Analysis: C, 76.70; H, 9.36; O, 13.93

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Org 2058; O-2058; Org-2058; Org2058
IUPAC/Chemical Name
16alpha-Ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione
InChi Key
IJLXLZGJDSJGIQ-BILPMHSYSA-N
InChi Code
InChI=1S/C22H32O3/c1-3-13-11-19-18-6-4-14-10-15(24)5-7-16(14)17(18)8-9-22(19,2)21(13)20(25)12-23/h10,13,16-19,21,23H,3-9,11-12H2,1-2H3/t13-,16+,17-,18-,19+,21-,22+/m1/s1
SMILES Code
C[C@@]12[C@@H](C(CO)=O)[C@H](CC)C[C@@]1([H])[C@]3([H])CCC4=CC(CC[C@]4([H])[C@@]3([H])CC2)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 344.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bakos T, Lökös M, Vincze I, Volford J. Steroids 51. An improved synthesis of ORG 2058 and the synthesis of [3H]ORG 2058. Steroids. 1993 Mar;58(3):115-8. PubMed PMID: 8475515. 2: Traish AM, Netsuwan N. 7 alpha-17 alpha-Dimethyl-19-nortestosterone (mibolerone) induces conformational changes in progesterone receptors distinct from those induced by ORG 2058. Steroids. 1994 Jun;59(6):362-70. PubMed PMID: 7940614. 3: Geier A, Bella R, Beery R, Lunenfeld B. Comparison of the physical properties of the nuclear progesterone receptor, bound to antiprogestin RU 486 or progestin ORG 2058, following limited proteolysis. Steroids. 1990 Jun;55(6):283-8. PubMed PMID: 2385853. 4: Geier A, Bella R, Beery R, Haimsohn M, Lunenfeld B. Differences in the association of the progesterone receptor ligated by antiprogestin RU38486 or progestin ORG 2058 to chromatin components. Biochim Biophys Acta. 1987 Oct 22;931(1):78-86. PubMed PMID: 3651513. 5: Sharoni Y, Feldman B, Karny N, Levy J. ORG-2058 as a ligand in the assay of progesterone receptor in breast cancer. Steroids. 1986 Nov-Dec;48(5-6):419-26. PubMed PMID: 3445291. 6: Weaker FJ, Sheridan PJ. Autoradiographic localization of 3H-ORG 2058, a synthetic progestin, in the mammary glands of the baboon. Breast Cancer Res Treat. 1984;4(2):143-7. PubMed PMID: 6743840. 7: Devriendt D, Ma Y, Kinnaert E, Journe F, Seo HS, Van Houtte P, Leclercq G. Effect of low dose irradiation on estrogen receptor level in MCF-7 breast cancer cells. Int J Cancer. 2001 Feb 20;96(1):32-40. PubMed PMID: 11241328. 8: Kloosterboer HJ, Vonk-Noordegraaf CA, Turpijn EW. Selectivity in progesterone and androgen receptor binding of progestagens used in oral contraceptives. Contraception. 1988 Sep;38(3):325-32. PubMed PMID: 3139361. 9: Capes-Davis A, Andrew SD, Hyland VJ, Twigg S, Learoyd DL, Dwight T, Marsh DJ, Robinson BG. Glucocorticoids differentially inhibit expression of the RET proto-oncogene. Gene Expr. 1999;8(5-6):311-26. PubMed PMID: 10947080; PubMed Central PMCID: PMC6157381. 10: Heubner A, Manz B, Grill HJ, Pollow K. High-performance and ion-exchange chromatography and chromatofocusing of the human uterine progesterone receptor: its application to the identification of 21-[3H]dehydro Org 2058-labelled receptor. J Chromatogr. 1984 Aug 3;297:301-11. PubMed PMID: 6548479. 11: Sar M. Distribution of progestin-concentrating cells in rat brain: colocalization of [3H]ORG.2058, a synthetic progestin, and antibodies to tyrosine hydroxylase in hypothalamus by combined autoradiography and immunocytochemistry. Endocrinology. 1988 Aug;123(2):1110-8. PubMed PMID: 2899499. 12: Ormandy CJ, Clarke CL, Kelly PA, Sutherland RL. Androgen regulation of prolactin-receptor gene expression in MCF-7 and MDA-MB-453 human breast cancer cells. Int J Cancer. 1992 Mar 12;50(5):777-82. PubMed PMID: 1544711. 13: Rees HD, Bonsall RW, Michael RP. Localization of the synthetic progestin 3H-ORG 2058 in neurons of the primate brain: evidence for the site of action of progestins on behavior. J Comp Neurol. 1985 May 15;235(3):336-42. PubMed PMID: 3998214. 14: Reddel RR, Alexander IE, Koga M, Shine J, Sutherland RL. Genetic instability and the development of steroid hormone insensitivity in cultured T 47D human breast cancer cells. Cancer Res. 1988 Aug 1;48(15):4340-7. PubMed PMID: 3390830. 15: Winborn WB, Sheridan PJ, McGill HC Jr. Localization of progestin receptors in the islets of Langerhans. Pancreas. 1987;2(3):289-94. PubMed PMID: 3306663. 16: Alexander IE, Clarke CL, Shine J, Sutherland RL. Progestin inhibition of progesterone receptor gene expression in human breast cancer cells. Mol Endocrinol. 1989 Sep;3(9):1377-86. PubMed PMID: 2608065. 17: van de Ven J, Donker GH, Sprong M, Blankenstein MA, Thijssen JH. Effect of tibolone (Org OD14) and its metabolites on aromatase and estrone sulfatase activity in human breast adipose stromal cells and in MCF-7 and T47D breast cancer cells. J Steroid Biochem Mol Biol. 2002 Jul;81(3):237-47. PubMed PMID: 12163135. 18: Meyer HH, Jewgenow K, Hodges JK. Binding activity of 5alpha-reduced gestagens to the progestin receptor from African elephant (Loxodonta africana). Gen Comp Endocrinol. 1997 Feb;105(2):164-7. PubMed PMID: 9038248. 19: Xiao CW, Goff AK. Hormonal regulation of oestrogen and progesterone receptors in cultured bovine endometrial cells. J Reprod Fertil. 1999 Jan;115(1):101-9. PubMed PMID: 10341728. 20: Traish AM, Williams DF, Wotiz HH. Binding of (3H)7 alpha,17 alpha-dimethyl-19-nortestosterone (mibolerone) to progesterone receptors: comparison with binding of (3H)R5020 and (3H)ORG2058. Steroids. 1986 Feb-Mar;47(2-3):157-73. PubMed PMID: 3564084.