MK0963 | CAS#103497-68-3

MedKoo Cat#: 532391 | Name: MK-0963

Description:

WARNING: This product is for research use only, not for human or veterinary use.

L-654066, also known as MK0963, is a new 5 alpha-reductase inhibitor. MK-0963 results in a substantial suppression of serum dihydrotestosterone with no consistent influence on serum testosterone concentrations.

Chemical Structure

MK-0963

CAS#103497-68-3

Theoretical Analysis

MedKoo Cat#: 532391

Name: MK-0963

CAS#: 103497-68-3

Chemical Formula: C23H35NO2

Exact Mass: 357.2668

Molecular Weight: 357.54

Elemental Analysis: C, 77.27; H, 9.87; N, 3.92; O, 8.95

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

L 654066; L-654066; L654066; MK 963; MK-963; MK963; MK0963; MK-0963; MK 0963;

IUPAC/Chemical Name

(5Alpha)-23-methyl-4-aza-21-norchol-1-ene-3,20-dione

InChi Key

RDPJISLOFXUIDK-RLAPWRJVSA-N

InChi Code

InChI=1S/C23H35NO2/c1-14(2)13-19(25)18-7-6-16-15-5-8-20-23(4,12-10-21(26)24-20)17(15)9-11-22(16,18)3/h10,12,14-18,20H,5-9,11,13H2,1-4H3,(H,24,26)/t15-,16-,17-,18+,20+,22-,23+/m0/s1

SMILES Code

CC(C)CC([C@H]1CC[C@@]2([H])[C@]3([H])CC[C@@]4([H])NC(C=C[C@]4(C)[C@@]3([H])CC[C@]12C)=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 357.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Olah TV, Gilbert JD, Barrish A, Greber TF, McLoughlin DA. A rapid and specific assay, based on liquid chromatography-atmospheric pressure chemical ionization mass spectrometry, for the determination of MK-434 (a 5 alpha- reductase inhibitor) and its metabolites in plasma. J Pharm Biomed Anal. 1994 May;12(5):705-12. doi: 10.1016/0731-7085(93)e0008-b. PMID: 7948192. 2: Schwartz JI, Laskin OL, Meeter CA, Patterson PM, Schneider SH, Lasseter KC, Seibold JR. Pharmacodynamics of MK-0963, a new 5 alpha-reductase inhibitor: effects on serum androgen concentrations. Clin Pharmacol Ther. 1994 Jan;55(1):50-4. doi: 10.1038/clpt.1994.9. PMID: 8299317. 3: Depré M, Meeter C, Van Hecken A, Laskin OL, Buntinx A, De Schepper PJ. Pharmacodynamics and tolerability of L-654,066, a steroid 5 alpha-reductase inhibitor, in men. Clin Pharmacol Ther. 1992 Oct;52(4):409-12. doi: 10.1038/clpt.1992.163. PMID: 1424413. 4: Gilbert JD, Olah TV, Barrish A, Greber TF. Determination of L-654,066, a new 5 alpha-reductase inhibitor in plasma by liquid chromatography/atmospheric pressure chemical ionization mass spectrometry. Biol Mass Spectrom. 1992 Jul;21(7):341-6. doi: 10.1002/bms.1200210704. PMID: 1420375.