KGP03 | Tubulin Inhibitor

MedKoo Cat#: 565314 | Name: KGP03

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KGP03 is a potent inhibitor of tubulin polymerization.

Chemical Structure

KGP03

CAS#NONE

Theoretical Analysis

MedKoo Cat#: 565314

Name: KGP03

CAS#: NONE

Chemical Formula: C20H22O5

Exact Mass: 342.1467

Molecular Weight: 342.39

Elemental Analysis: C, 70.16; H, 6.48; O, 23.36

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

KGP03; KGP 03; KGP-03

IUPAC/Chemical Name

2-Methoxy-5-(3,4,5-trimethoxyphenyl)-7,8-dihydronaphthalen-1-ol

InChi Key

KMHXPLFYVAJLJK-UHFFFAOYSA-N

InChi Code

InChI=1S/C20H22O5/c1-22-16-9-8-14-13(6-5-7-15(14)19(16)21)12-10-17(23-2)20(25-4)18(11-12)24-3/h6,8-11,21H,5,7H2,1-4H3

SMILES Code

OC1=C2CCC=C(C3=CC(OC)=C(OC)C(OC)=C3)C2=CC=C1OC

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 342.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Niu H, Strecker TE, Gerberich JL, Campbell J, Saha D, Mondal D, Hamel E, Chaplin DJ, Mason RP, Trawick ML, Pinney KG. Structure Guided Design, Synthesis, and Biological Evaluation of Novel Benzosuberene Analogues as Inhibitors of Tubulin Polymerization. J Med Chem. 2019 May 6. doi: 10.1021/acs.jmedchem.9b00551. [Epub ahead of print] PubMed PMID: 31059248. 2: Maguire CJ, Chen Z, Mocharla VP, Sriram M, Strecker TE, Hamel E, Zhou H, Lopez R, Wang Y, Mason RP, Chaplin DJ, Trawick ML, Pinney KG. Synthesis of dihydronaphthalene analogues inspired by combretastatin A-4 and their biological evaluation as anticancer agents. Medchemcomm. 2018 Aug 24;9(10):1649-1662. doi: 10.1039/c8md00322j. eCollection 2018 Oct 1. PubMed PMID: 30429970; PubMed Central PMCID: PMC6201230.