MedKoo Cat#: 573618 | Name: Norspermine
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Norspermine is a polyamine analogue which may be useful in the treatment of non-small cell lung carcinoma and breast cancer.

Chemical Structure

Norspermine
Norspermine
CAS#4605-14-5

Theoretical Analysis

MedKoo Cat#: 573618

Name: Norspermine

CAS#: 4605-14-5

Chemical Formula: C9H24N4

Exact Mass: 188.2001

Molecular Weight: 188.32

Elemental Analysis: C, 57.40; H, 12.85; N, 29.75

Price and Availability

Size Price Availability Quantity
1g USD 350.00 2 Weeks
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Related CAS #
No Data
Synonym
AI3-61617, Norspermine, Norspermidine
IUPAC/Chemical Name
1,3-Propanediamine, N,N'-bis(3-aminopropyl)-
InChi Key
ZAXCZCOUDLENMH-UHFFFAOYSA-N
InChi Code
1S/C9H24N4/c10-4-1-6-12-8-3-9-13-7-2-5-11/h12-13H,1-11H2
SMILES Code
N(CCCNCCCN)CCCN
Appearance
liquid
Purity
>97% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Certificate of Analysis
Safety Data Sheet (SDS)
Biological target:
Norspermine is a polyamine analogue which may be useful in the treatment of non-small cell lung carcinoma and breast cancer.
In vitro activity:
TBD
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 188.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
1: Nair SK, Verma A, Thomas TJ, Chou TC, Gallo MA, Shirahata A, Thomas T. Synergistic apoptosis of MCF-7 breast cancer cells by 2-methoxyestradiol and bis(ethyl)norspermine. Cancer Lett. 2007 Jun 8;250(2):311-22. Epub 2006 Dec 20. PubMed PMID: 17184909; PubMed Central PMCID: PMC1899838. 2: Gabrielson EW, Pegg AE, Casero RA Jr. The induction of spermidine/spermine N1-acetyltransferase (SSAT) is a common event in the response of human primary non-small cell lung carcinomas to exposure to the new antitumor polyamine analogue N1,N11-bis(ethyl)norspermine. Clin Cancer Res. 1999 Jul;5(7):1638-41. PubMed PMID: 10430062. 3: Porter CW, Bernacki RJ, Miller J, Bergeron RJ. Antitumor activity of N1,N11-bis(ethyl)norspermine against human melanoma xenografts and possible biochemical correlates of drug action. Cancer Res. 1993 Feb 1;53(3):581-6. PubMed PMID: 8425191.