Methionine sulfoximine | CAS# 1982-67-8 | Glutamine Synthetase Inhibitor

MedKoo Cat#: 573613 | Name: Methionine sulfoximine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Methionine sulfoximine (MSO) is an irreversible glutamine synthetase inhibitor. It is the sulfoximine derivative of methionine with convulsant effects.

Chemical Structure

Methionine sulfoximine

CAS#1982-67-8

Theoretical Analysis

MedKoo Cat#: 573613

Name: Methionine sulfoximine

CAS#: 1982-67-8

Chemical Formula: C5H12N2O3S

Exact Mass: 180.0569

Molecular Weight: 180.22

Elemental Analysis: C, 33.32; H, 6.71; N, 15.54; O, 26.63; S, 17.79

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

AI3-62723, DL-Methionine-DL-sulfoximine, Methionine sulfoximine

IUPAC/Chemical Name

2-Amino-4-(S-methylsulphonimidoyl)butyric acid

InChi Key

SXTAYKAGBXMACB-UHFFFAOYSA-N

InChi Code

1S/C5H12N2O3S/c1-11(7,10)3-2-4(6)5(8)9/h4,7H,2-3,6H2,1H3,(H,8,9)

SMILES Code

S(=O)(=N)(CCC(C(=O)O)N)C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 180.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Brusilow WS. Identification of the isomer of methionine sulfoximine that extends the lifespan of the SOD1 G93A mouse. Neurosci Lett. 2017 Apr 24;647:165-167. doi: 10.1016/j.neulet.2017.03.029. Epub 2017 Mar 18. PubMed PMID: 28323087. 2: Yu DY, Noh SM, Lee GM. Limitations to the development of recombinant human embryonic kidney 293E cells using glutamine synthetase-mediated gene amplification: Methionine sulfoximine resistance. J Biotechnol. 2016 Aug 10;231:136-140. doi: 10.1016/j.jbiotec.2016.06.003. Epub 2016 Jun 8. PubMed PMID: 27288593. 3: Manning JM, Moore S, Rowe WB, Meister A. Identification of L-methionine S-sulfoximine as the diastereoisomer of L-methionine SR-sulfoximine that inhibits glutamine synthetase. Biochemistry. 1969 Jun;8(6):2681-5. PubMed PMID: 5799144.