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MedKoo Cat#: 555538 | Name: PF-6751979

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PF-6751979 is a BCEA1 inhibitor.

Chemical Structure

PF-6751979
PF-6751979
CAS#Unknown

Theoretical Analysis

MedKoo Cat#: 555538

Name: PF-6751979

CAS#: Unknown

Chemical Formula: C19H21F2N5O3S2

Exact Mass: 469.1054

Molecular Weight: 469.53

Elemental Analysis: C, 48.60; H, 4.51; F, 8.09; N, 14.92; O, 10.22; S, 13.66

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
PF-6751979; PF 6751979; PF6751979;
IUPAC/Chemical Name
N-(2-((4aR,6S,8aR)-2-amino-4a,6-dimethyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl)thiazol-4-yl)-5-(difluoromethoxy)picolinamide
InChi Key
PQWLGKOGBRNRST-WQZPPZBRSA-N
InChi Code
InChI=1S/C19H21F2N5O3S2/c1-10-5-18(2)9-31-17(22)26-19(18,8-28-10)15-25-13(7-30-15)24-14(27)12-4-3-11(6-23-12)29-16(20)21/h3-4,6-7,10,16H,5,8-9H2,1-2H3,(H2,22,26)(H,24,27)/t10-,18-,19+/m0/s1
SMILES Code
O=C(NC1=CSC([C@@]23N=C(N)SC[C@]2(C)C[C@H](C)OC3)=N1)C4=NC=C(OC(F)F)C=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 469.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Structure-Based Design of Selective β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: Targeting the Flap to Gain Selectivity over BACE2 Kazuki Fujimoto, Eriko Matsuoka, Naoya Asada, Genta Tadano, Takahiko Yamamoto, Kenji Nakahara, Kouki Fuchino, Hisanori Ito, Naoki Kanegawa, Diederik Moechars, Harrie J. M. Gijsen, and Ken-ichi Kusakabe Publication Date (Web): April 25, 2019 (Article) DOI: 10.1021/acs.jmedchem.9b00309