MedKoo Cat#: 573608 | Name: TES free acid
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

TES free acid is a structural analog to Tris buffer. It is one of the ethanesulfonic acid series of biological buffers developed by Good et al. Good's buffer criteria: midrange pKa, maximum water solubility and minimum solubility in all other solvents, minimal salt effects, minimal change in pKa with temperature, chemically and enzymatically stable, minimal absorption in visible or UV spectral range, and easily synthesized. TES probably exists in solution as a zwitterion.

Chemical Structure

TES free acid
CAS#7365-44-8

Theoretical Analysis

MedKoo Cat#: 573608

Name: TES free acid

CAS#: 7365-44-8

Chemical Formula: C6H15NO6S

Exact Mass: 229.0620

Molecular Weight: 229.25

Elemental Analysis: C, 31.44; H, 6.60; N, 6.11; O, 41.87; S, 13.98

Price and Availability

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100g USD 360.00
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Related CAS #
No Data
Synonym
AI3-62522, TES free acid
IUPAC/Chemical Name
Ethanesulfonic acid, 2-((2-hydroxy-1,1-bis(hydroxymethyl)ethyl)amino)-
InChi Key
JOCBASBOOFNAJA-UHFFFAOYSA-N
InChi Code
1S/C6H15NO6S/c8-3-6(4-9,5-10)7-1-2-14(11,12)13/h7-10H,1-5H2,(H,11,12,13)
SMILES Code
O=S(=O)(O)CCNC(CO)(CO)CO
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Because the pKa is 7.4 (physiological pH) this buffer has considerable potential for a variety of biological applications. A buffer using TES free acid can be prepared by titrating the free acid (sc-206102) with sodium hydroxide to the desired pH, using about a half-equivalent of NaOH. Alternatively, solutions of equimolar TES free acid and TES sodium (sc-264384) can be mixed to attain a buffer of the desired pH.

Preparing Stock Solutions

The following data is based on the product molecular weight 229.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Good, N.E., et al. 1966. Biochemistry. 5: 467-477. PMID: 5942950