Synonym
KKL-35; KKL 35; KKL35;
IUPAC/Chemical Name
3-chloro-N-(1-propyl-1H-tetrazol-5-yl)benzamide
InChi Key
IBRCUOMIAFDQTM-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H12ClN5O/c1-2-6-17-11(14-15-16-17)13-10(18)8-4-3-5-9(12)7-8/h3-5,7H,2,6H2,1H3,(H,13,14,16,18)
SMILES Code
O=C(NC1=NN=NN1CCC)C2=CC=CC(Cl)=C2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
trans-Translation is a ribosome-rescue system that is ubiquitous in bacteria. Small molecules defining a new family of oxadiazole compounds that inhibit trans-translation have been found to have broad-spectrum antibiotic activity.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
265.70
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Brunel R, Descours G, Durieux I, Doublet P, Jarraud S, Charpentier X. KKL-35
Exhibits Potent Antibiotic Activity against Legionella Species Independently of
trans-Translation Inhibition. Antimicrob Agents Chemother. 2018 Jan 25;62(2).
pii: e01459-17. doi: 10.1128/AAC.01459-17. Print 2018 Feb. PubMed PMID: 29158279;
PubMed Central PMCID: PMC5786812.
2: Macé K, Demay F, Guyomar C, Georgeault S, Giudice E, Goude R, Trautwetter A,
Ermel G, Blanco C, Gillet R. A Genetic Tool to Quantify trans-Translation
Activity in Vivo. J Mol Biol. 2017 Nov 24;429(23):3617-3625. doi:
10.1016/j.jmb.2017.10.007. Epub 2017 Oct 13. PubMed PMID: 29031699.
3: Alumasa JN, Manzanillo PS, Peterson ND, Lundrigan T, Baughn AD, Cox JS, Keiler
KC. Ribosome Rescue Inhibitors Kill Actively Growing and Nonreplicating Persister
Mycobacterium tuberculosis Cells. ACS Infect Dis. 2017 Sep 8;3(9):634-644. doi:
10.1021/acsinfecdis.7b00028. Epub 2017 Aug 7. PubMed PMID: 28762275; PubMed
Central PMCID: PMC5594445.
4: Ramadoss NS, Alumasa JN, Cheng L, Wang Y, Li S, Chambers BS, Chang H,
Chatterjee AK, Brinker A, Engels IH, Keiler KC. Small molecule inhibitors of
trans-translation have broad-spectrum antibiotic activity. Proc Natl Acad Sci U S
A. 2013 Jun 18;110(25):10282-7. doi: 10.1073/pnas.1302816110. Epub 2013 Jun 3.
PubMed PMID: 23733947; PubMed Central PMCID: PMC3690859.
