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MedKoo Cat#: 565287 | Name: AT-1012

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AT-1012 is a high affinity, selective alpha3beta4 nAChR ligand.

Chemical Structure

AT-1012
AT-1012
CAS#NONE

Theoretical Analysis

MedKoo Cat#: 565287

Name: AT-1012

CAS#: NONE

Chemical Formula: C15H21IN2

Exact Mass: 356.0749

Molecular Weight: 356.25

Elemental Analysis: C, 50.57; H, 5.94; I, 35.62; N, 7.86

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
AT1012; AT 1012; AT-1012
IUPAC/Chemical Name
(1R,3r,5S)-N-(2-Iodophenyl)-9-methyl-9-azabicyclo[3.3.1]nonan-3-amine
InChi Key
PEABIRMUXLEPPM-CLLJXQQHSA-N
InChi Code
InChI=1S/C15H21IN2/c1-18-12-5-4-6-13(18)10-11(9-12)17-15-8-3-2-7-14(15)16/h2-3,7-8,11-13,17H,4-6,9-10H2,1H3/t11-,12+,13-
SMILES Code
IC1=CC=CC=C1N[C@H]2C[C@H]3CCC[C@H](N3C)C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 356.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Khroyan TV, Yasuda D, Toll L, Polgar WE, Zaveri NT. High affinity α3β4 nicotinic acetylcholine receptor ligands AT-1001 and AT-1012 attenuate cocaine-induced conditioned place preference and behavioral sensitization in mice. Biochem Pharmacol. 2015 Oct 15;97(4):531-541. doi: 10.1016/j.bcp.2015.08.083. Epub 2015 Aug 7. PubMed PMID: 26256075; PubMed Central PMCID: PMC4600456. 2: Wu J, Perry DC, Bupp JE, Jiang F, Polgar WE, Toll L, Zaveri NT. [¹²⁵I]AT-1012, a new high affinity radioligand for the α3β4 nicotinic acetylcholine receptors. Neuropharmacology. 2014 Feb;77:193-9. doi: 10.1016/j.neuropharm.2013.09.023. Epub 2013 Oct 3. PubMed PMID: 24095990; PubMed Central PMCID: PMC3866371.