MedKoo Cat#: 565274 | Name: AVG-233

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AVG-233 is a first-in-class specific blocker of the RSV RNA-dependent RNA polymerase (RdRp) complex.

Chemical Structure

AVG-233
AVG-233
CAS#NONE

Theoretical Analysis

MedKoo Cat#: 565274

Name: AVG-233

CAS#: NONE

Chemical Formula: C26H22ClN5O3

Exact Mass: 487.1411

Molecular Weight: 487.94

Elemental Analysis: C, 64.00; H, 4.54; Cl, 7.27; N, 14.35; O, 9.84

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
AVG233; AVG 233; AVG-233
IUPAC/Chemical Name
5-((6-Chloropyridin-2-yl)methyl)-1-(4-methoxybenzyl)-4-methyl-2-(pyridin-2-yl)-1,2-dihydro-3H-pyrazolo[4,3-c]pyridine-3,6(5H)-dione
InChi Key
CXZZYJLIYWCICH-UHFFFAOYSA-N
InChi Code
InChI=1S/C26H22ClN5O3/c1-17-25-21(14-24(33)30(17)16-19-6-5-7-22(27)29-19)31(15-18-9-11-20(35-2)12-10-18)32(26(25)34)23-8-3-4-13-28-23/h3-14H,15-16H2,1-2H3
SMILES Code
O=C1N(C2=NC=CC=C2)N(CC3=CC=C(OC)C=C3)C(C1=C(C)N4CC5=NC(Cl)=CC=C5)=CC4=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 487.94 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Cox RM, Toots M, Yoon JJ, Sourimant J, Ludeke B, Fearns R, Bourque E, Patti J, Lee E, Vernachio J, Plemper RK. Development of an allosteric inhibitor class blocking RNA elongation by the respiratory syncytial virus polymerase complex. J Biol Chem. 2018 Oct 26;293(43):16761-16777. doi: 10.1074/jbc.RA118.004862. Epub 2018 Sep 11. PubMed PMID: 30206124; PubMed Central PMCID: PMC6204889.