MedKoo Cat#: 565262 | Name: NPT200-11
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

NPT200-11, also known as UCB0599, is an alpha-synuclein (ASYN) misfolding inhibitor which produces multiple benefits in an animal model of Parkinson's disease

Chemical Structure

NPT200-11
NPT200-11
CAS#2227057-23-8

Theoretical Analysis

MedKoo Cat#: 565262

Name: NPT200-11

CAS#: 2227057-23-8

Chemical Formula: C28H39N5O3

Exact Mass: 493.3053

Molecular Weight: 493.65

Elemental Analysis: C, 68.13; H, 7.96; N, 14.19; O, 9.72

Price and Availability

Size Price Availability Quantity
5mg USD 950.00 2 Weeks
10mg USD 1,650.00 2 Weeks
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Related CAS #
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Synonym
NPT20011; NPT200 11; NPT200-11; UCB0599; UCB-0599; UCB 0599;
IUPAC/Chemical Name
1-(3-(1H-Indol-3-yl)propanoyl)-6-butyl-8-(piperidin-4-ylmethyl)hexahydro-4H-pyrazino[1,2-a]pyrimidine-4,7(6H)-dione
InChi Key
KDAJSQJISXIJTN-UHFFFAOYSA-N
InChi Code
InChI=1S/C28H39N5O3/c1-2-3-8-24-28(36)31(18-20-11-14-29-15-12-20)19-25-32(16-13-27(35)33(24)25)26(34)10-9-21-17-30-23-7-5-4-6-22(21)23/h4-7,17,20,24-25,29-30H,2-3,8-16,18-19H2,1H3
SMILES Code
O=C1CCN(C(CCC2=CNC3=C2C=CC=C3)=O)C(CN4CC5CCNCC5)N1C(CCCC)C4=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 493.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hershey LA, Coleman-Jackson R. Pharmacological Management of Dementia with Lewy Bodies. Drugs Aging. 2019 Apr;36(4):309-319. doi: 10.1007/s40266-018-00636-7. Review. PubMed PMID: 30680679; PubMed Central PMCID: PMC6435621. 2: Price DL, Koike MA, Khan A, Wrasidlo W, Rockenstein E, Masliah E, Bonhaus D. The small molecule alpha-synuclein misfolding inhibitor, NPT200-11, produces multiple benefits in an animal model of Parkinson's disease. Sci Rep. 2018 Nov 1;8(1):16165. doi: 10.1038/s41598-018-34490-9. PubMed PMID: 30385782; PubMed Central PMCID: PMC6212487.