NSC30049 | Chk1 Inhibitor

MedKoo Cat#: 565257 | Name: NSC30049

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NSC30049 is an inhibitor of Chk1 pathway in 5-FU-resistant CRC bulk and stem cell populations.

Chemical Structure

NSC30049

CAS#NONE

Theoretical Analysis

MedKoo Cat#: 565257

Name: NSC30049

CAS#: NONE

Chemical Formula: C10H18Cl2N4

Exact Mass:

Molecular Weight: 265.18

Elemental Analysis: C, 45.29; H, 6.84; Cl, 26.74; N, 21.13

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

NSC49L; NSC-30049; NSC 30049; NSC30049

IUPAC/Chemical Name

1-((E)-4-Chlorobut-2-en-1-yl)-1,3,5,7-tetraazaadamantan-1-ium Chloride

InChi Key

AXSUDOUXNCTJMM-TYYBGVCCSA-M

InChi Code

InChI=1S/C10H18ClN4.ClH/c11-3-1-2-4-15-8-12-5-13(9-15)7-14(6-12)10-15;/h1-2H,3-10H2;1H/q+1;/p-1/b2-1+;

SMILES Code

ClC/C=C/C[N+]12CN3CN(C2)CN(C3)C1.[Cl-]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 265.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Narayan S, Ramisetti S, Jaiswal AS, Law BK, Singh-Pillay A, Singh P, Amin S, Sharma AK. ASR352, A potent anticancer agent: Synthesis, preliminary SAR, and biological activities against colorectal cancer bulk, 5-fluorouracil/oxaliplatin resistant and stem cells. Eur J Med Chem. 2019 Jan 1;161:456-467. doi: 10.1016/j.ejmech.2018.10.052. Epub 2018 Oct 23. PubMed PMID: 30384048. 2: Narayan S, Jaiswal AS, Sharma R, Nawab A, Duckworth LV, Law BK, Zajac-Kaye M, George TJ, Sharma J, Sharma AK, Hromas RA. NSC30049 inhibits Chk1 pathway in 5-FU-resistant CRC bulk and stem cell populations. Oncotarget. 2017 Aug 1;8(34):57246-57264. doi: 10.18632/oncotarget.19778. eCollection 2017 Aug 22. PubMed PMID: 28915668; PubMed Central PMCID: PMC5593639.