MedKoo Cat#: 407999 | Name: LAF-153

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LAF-153 is a reversible Methionine Aminopeptidase‑2 (MetAP-2) Inhibitor.

Chemical Structure

LAF-153
LAF-153
CAS#661482-39-9

Theoretical Analysis

MedKoo Cat#: 407999

Name: LAF-153

CAS#: 661482-39-9

Chemical Formula: C18H34N2O6

Exact Mass: 374.2417

Molecular Weight: 374.48

Elemental Analysis: C, 57.73; H, 9.15; N, 7.48; O, 25.63

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
LAF-153; LAF 153; LAF153;
IUPAC/Chemical Name
(3S,6R)-6-hydroxy-3-(((2S,3R,4S,5R,E)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-en-1-yl)amino)azepan-2-one
InChi Key
JKGVCCOXLJBDCT-RUPMKCBVSA-N
InChi Code
InChI=1S/C18H34N2O6/c1-18(2,3)8-7-13(22)15(23)16(24)14(26-4)10-19-12-6-5-11(21)9-20-17(12)25/h7-8,11-16,19,21-24H,5-6,9-10H2,1-4H3,(H,20,25)/b8-7+/t11-,12+,13-,14+,15+,16+/m1/s1
SMILES Code
O=C1[C@@H](NC[C@H](OC)[C@H](O)[C@@H](O)[C@H](O)/C=C/C(C)(C)C)CC[C@@H](O)CN1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 374.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Discovery and Structure-Based Optimization of Next-Generation Reversible Methionine Aminopeptidase-2 (MetAP-2) Inhibitors Timo Heinrich, Jeyaprakashnarayanan Seenisamy, Beatrix Blume, Jörg Bomke, Michel Calderini, Uwe Eckert, Manja Friese-Hamim, Rainer Kohl, Martin Lehmann, Birgitta Leuthner, Djordje Musil, Felix Rohdich, and Frank T. Zenke Publication Date (Web): April 2, 2019 (Article) DOI: 10.1021/acs.jmedchem.9b00041