Synonym
Opc 8490; Opc-8490; Opc8490
IUPAC/Chemical Name
Piperazine, 1-(4-oxo-4-phenylbutyl)-4-((1,2,3,4-tetrahydro-2-oxo-6-quinolinyl)carbonyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)
InChi Key
ONELTIQETCJUSG-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H27N3O3.C6H8O7/c28-22(18-5-2-1-3-6-18)7-4-12-26-13-15-27(16-14-26)24(30)20-8-10-21-19(17-20)9-11-23(29)25-21;7-3(8)1-6(13,5(11)12)2-4(9)10/h1-3,5-6,8,10,17H,4,7,9,11-16H2,(H,25,29);13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
SMILES Code
O=C(N1CCN(CCCC(C2=CC=CC=C2)=O)CC1)C3=CC4=C(NC(CC4)=O)C=C3.O=C(CC(C(O)=O)(O)CC(O)=O)O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
597.62
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Focaccio A, Peeters G, Movsesian M, Roden R, Eki Y, Krall J, Bristow MR. Mechanism of action of OPC-8490 in human ventricular myocardium. Circulation. 1996 Feb 15;93(4):817-25. PubMed PMID: 8641012.
2: Kurachi Y, Asano Y, Ito H, Sugimoto T. Voltage-dependent inhibition of the delayed outward potassium current by OPC-8490, a novel positive inotropic agent, in isolated atrial myocytes of guinea-pig heart. Naunyn Schmiedebergs Arch Pharmacol. 1990 Apr;341(4):324-30. PubMed PMID: 1692107.
3: Furukawa Y, Akahane K, Haniuda M, Chiba S. Positive inotropic and negative chronotropic effects of OPC-8490, a newly developed cardiotonic, in isolated, blood-perfused canine heart preparations. Jpn Heart J. 1989 May;30(3):387-98. PubMed PMID: 2552190.
4: Endoh M, Satoh H, Norota I, Hirano K, Hosokawa T. Subcellular mechanism of the positive inotropic effect of a new quinolinone derivative OPC-8490 on the dog ventricular myocardium. Heart Vessels. 1991;6(3):158-67. PubMed PMID: 1655692.
5: Momose Y, Sasayama S. Effect of OPC-8490 on the membrane potentials and membrane currents of single guinea-pig myocytes. Cardiovasc Drugs Ther. 1990 Jun;4(3):713-7. PubMed PMID: 1963791.
6: Kameyama T, Asanoi H, Ishizaka S, Nozawa T, Fujita M, Sasayama S. [End-systolic pressure-volume relationships obtained by conductance catheter and transient inferior vena caval occlusion: their clinical usefulness]. J Cardiol. 1991;21(2):473-80. Japanese. PubMed PMID: 1668750.
