Synonym
Disodium sebacate; Decanedioic Acid Disodium Salt; Disodium Decanedioate; Sebacic Acid Disodium Salt.
IUPAC/Chemical Name
Decanedioic acid, disodium salt
InChi Key
NCXUIEDQTCQZRK-UHFFFAOYSA-L
InChi Code
InChI=1S/C10H18O4.2Na/c11-9(12)7-5-3-1-2-4-6-8-10(13)14;;/h1-8H2,(H,11,12)(H,13,14);;/q;2*+1/p-2
SMILES Code
[Na+].[Na+].C(CCCCCCCCC(=O)[O-])(=O)[O-]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
246.21
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Favuzzi AM, Mingrone G, Bertuzzi A, Salinari S, Gandolfi A, Greco AV. Pharmacokinetics of sebacic acid in rats. Eur Rev Med Pharmacol Sci. 1999 May-Jun;3(3):119-25. PubMed PMID: 10827815.
2: Mingrone G, Greco AV, Castagneto M, De Gaetano A, Tataranni PA, Raguso C. Kinetics and thermogenesis of medium-chain monocarboxylic and dicarboxylic acids in man: sebacate and medium-chain triglycerides. JPEN J Parenter Enteral Nutr. 1993 May-Jun;17(3):257-64. PubMed PMID: 8505832.
3: Bertuzzi A, Finotti E, Mingrone G, Greco AV. Sebacic acid binding to human plasma albumin. Biochem Pharmacol. 1993 Feb 9;45(3):697-702. PubMed PMID: 8442769.
4: Greco AV, Mingrone G, Raguso C, Tataranni A, Finotti E, Tacchino RM, Capristo E, De Gaetano A, Castagneto M. Metabolic effects and disposition of sebacate, an alternate dicarboxylic fuel substrate. Ann Nutr Metab. 1992;36(1):1-11. PubMed PMID: 1590667.
5: Tataranni PA, Mingrone G, De Gaetano A, Raguso C, Greco AV. Tracer study of metabolism and tissue distribution of sebacic acid in rats. Ann Nutr Metab. 1992;36(5-6):296-303. PubMed PMID: 1492757.
6: Mingrone G, Greco AV, Bertuzzi A, Arcieri-Mastromattei E, Tacchino RM, Marino F, Finotti E, Castagneto M. Tissue uptake and oxidation of disodium sebacate in man. JPEN J Parenter Enteral Nutr. 1991 Jul-Aug;15(4):454-9. PubMed PMID: 1910110.
7: Greco AV, Mingrone G, Arcieri Mastromattei E, Finotti E, Castagneto M. Toxicity of disodium sebacate. Drugs Exp Clin Res. 1990;16(10):531-6. PubMed PMID: 2100736.
