ARN2508 | FAAH/COX Inhibitor

MedKoo Cat#: 565203 | Name: ARN2508

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ARN2508 is a dual inhibitor of the fatty acid amide hydrolase (FAAH) and the cyclooxygenase (COX) enzymes.

Chemical Structure

ARN2508

CAS#NONE

Theoretical Analysis

MedKoo Cat#: 565203

Name: ARN2508

CAS#: NONE

Chemical Formula: C22H26FNO4

Exact Mass: 387.1846

Molecular Weight: 387.45

Elemental Analysis: C, 68.20; H, 6.76; F, 4.90; N, 3.62; O, 16.52

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

ARN-2508; ARN 2508; ARN2508

IUPAC/Chemical Name

2-[3-Fluoro-4-[3-(hexylcarbamoyloxy)phenyl]phenyl]-propanoic acid

InChi Key

USQOVYLRWBOSQC-UHFFFAOYSA-N

InChi Code

InChI=1S/C22H26FNO4/c1-3-4-5-6-12-24-22(27)28-18-9-7-8-17(13-18)19-11-10-16(14-20(19)23)15(2)21(25)26/h7-11,13-15H,3-6,12H2,1-2H3,(H,24,27)(H,25,26)

SMILES Code

CC(C1=CC=C(C2=CC=CC(OC(NCCCCCC)=O)=C2)C(F)=C1)C(O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 387.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Goodman MC, Xu S, Rouzer CA, Banerjee S, Ghebreselasie K, Migliore M, Piomelli D, Marnett LJ. Dual cyclooxygenase-fatty acid amide hydrolase inhibitor exploits novel binding interactions in the cyclooxygenase active site. J Biol Chem. 2018 Mar 2;293(9):3028-3038. doi: 10.1074/jbc.M117.802058. Epub 2018 Jan 11. PubMed PMID: 29326169; PubMed Central PMCID: PMC5836124. 2: Migliore M, Habrant D, Sasso O, Albani C, Bertozzi SM, Armirotti A, Piomelli D, Scarpelli R. Potent multitarget FAAH-COX inhibitors: Design and structure-activity relationship studies. Eur J Med Chem. 2016 Feb 15;109:216-37. doi: 10.1016/j.ejmech.2015.12.036. Epub 2015 Dec 23. PubMed PMID: 26774927; PubMed Central PMCID: PMC4752335. 3: Palermo G, Favia AD, Convertino M, De Vivo M. The Molecular Basis for Dual Fatty Acid Amide Hydrolase (FAAH)/Cyclooxygenase (COX) Inhibition. ChemMedChem. 2016 Jun 20;11(12):1252-8. doi: 10.1002/cmdc.201500507. Epub 2015 Nov 23. PubMed PMID: 26593700; PubMed Central PMCID: PMC5063142. 4: Sasso O, Migliore M, Habrant D, Armirotti A, Albani C, Summa M, Moreno-Sanz G, Scarpelli R, Piomelli D. Multitarget fatty acid amide hydrolase/cyclooxygenase blockade suppresses intestinal inflammation and protects against nonsteroidal anti-inflammatory drug-dependent gastrointestinal damage. FASEB J. 2015 Jun;29(6):2616-27. doi: 10.1096/fj.15-270637. Epub 2015 Mar 10. PubMed PMID: 25757568; PubMed Central PMCID: PMC4447230.