Synonym
Bometolol; OPC 1427; OPC-1427; OPC1427
IUPAC/Chemical Name
(+-)-8-(Acetonyloxy)-5-(3-((3,4-dimethoxyphenethyl)amino)-2-hydroxypropoxy)-3,4-dihydrocarbostyril
InChi Key
IXJJPGSXJXQFGI-UHFFFAOYSA-N
InChi Code
InChI=1S/C25H32N2O7/c1-16(28)14-33-22-8-7-20(19-5-9-24(30)27-25(19)22)34-15-18(29)13-26-11-10-17-4-6-21(31-2)23(12-17)32-3/h4,6-8,12,18,26,29H,5,9-11,13-15H2,1-3H3,(H,27,30)
SMILES Code
O=C1NC2=C(C(OCC(O)CNCCC3=CC=C(OC)C(OC)=C3)=CC=C2OCC(C)=O)CC1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
472.54
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Sugawara K, Takami N, Ozaki M. Hypotensive action of OPC-1427, a new beta-adrenergic blocking agent in rats. Arch Int Pharmacodyn Ther. 1979 Aug;240(2):294-304. PubMed PMID: 41497.
2: Watanabe TX, Watanabe Y, Hasegawa Y, Kudo Y, Kawashima K, Sokabe H. Acute and subchronic effects of bometolol on blood pressure in hypertensive rats. J Pharmacobiodyn. 1981 Jul;4(7):505-12. PubMed PMID: 6117612.
3: Kudo Y, Sokabe H, Zehr JE. A simple method to determine the ratio of cardiac to vascular beta-receptor blockade in the rat in vivo. J Pharmacobiodyn. 1981 Jul;4(7):475-82. PubMed PMID: 6117611.
4: Hashimoto K, Satoh H, Shibuya T, Imai S. Canine-effective plasma concentrations of antiarrhythmic drugs on the two-stage coronary ligation arrhythmia. J Pharmacol Exp Ther. 1982 Dec;223(3):801-10. PubMed PMID: 7143241.
5: Tominaga M, Tone H, Nakagawa K, Takada K, Hoshino Y, Watanabe K. Syntheses and beta-adrenergic blocking activities of carbostyril derivatives. Chem Pharm Bull (Tokyo). 1981 Aug;29(8):2166-81. PubMed PMID: 6119165.
6: Yo E, Nakagawa K, Hoshino Y. Syntheses and beta-adrenergic blocking activities of the optical isomers of 8-acetonyloxyl-5-[3-(3,4-dimethoxyphenethylamino)-2-hydroxypropoxy]-3,4-dihydroca rbostyril. Chem Pharm Bull (Tokyo). 1981 Aug;29(8):2157-60. PubMed PMID: 6119164.
