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MedKoo Cat#: 565201 | Name: DC-034

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DC-034 is a potent downregulator of MYC transcription in cancer cells by a G4-dependent mechanism, thereby selectively inhibiting MYC significantly greater than other G4-driven genes.

Chemical Structure

DC-034
DC-034
CAS#1966107-70-9

Theoretical Analysis

MedKoo Cat#: 565201

Name: DC-034

CAS#: 1966107-70-9

Chemical Formula: C24H25F3N2O3

Exact Mass: 446.1817

Molecular Weight: 446.47

Elemental Analysis: C, 64.57; H, 5.64; F, 12.77; N, 6.27; O, 10.75

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
DC34; DC 34; DC-34; DC034; DC 034; DC-034
IUPAC/Chemical Name
4-(Azepan-1-ylmethyl)-5-hydroxy-2-methyl-N-(4-(trifluoromethyl)phenyl)benzofuran-3-carboxamide
InChi Key
CCAKHVBCBLIIEV-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H25F3N2O3/c1-15-21(23(31)28-17-8-6-16(7-9-17)24(25,26)27)22-18(19(30)10-11-20(22)32-15)14-29-12-4-2-3-5-13-29/h6-11,30H,2-5,12-14H2,1H3,(H,28,31)
SMILES Code
O=C(C1=C(C)OC2=CC=C(O)C(CN3CCCCCC3)=C12)NC4=CC=C(C(F)(F)F)C=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 446.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Calabrese DR, Chen X, Leon EC, Gaikwad SM, Phyo Z, Hewitt WM, Alden S, Hilimire TA, He F, Michalowski AM, Simmons JK, Saunders LB, Zhang S, Connors D, Walters KJ, Mock BA, Schneekloth JS Jr. Chemical and structural studies provide a mechanistic basis for recognition of the MYC G-quadruplex. Nat Commun. 2018 Oct 12;9(1):4229. doi: 10.1038/s41467-018-06315-w. PubMed PMID: 30315240; PubMed Central PMCID: PMC6185959.

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