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MedKoo Cat#: 584914 | Name: STA 2

Description:

WARNING: This product is for research use only, not for human or veterinary use.

STA 2 is an analogue of TXA2, a thromboxane receptor in the colonic epithelium.

Chemical Structure

STA 2
CAS#89617-02-7

Theoretical Analysis

MedKoo Cat#: 584914

Name: STA 2

CAS#: 89617-02-7

Chemical Formula: C21H34O3S

Exact Mass: 366.2229

Molecular Weight: 366.56

Elemental Analysis: C, 68.81; H, 9.35; O, 13.09; S, 8.75

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
STA 2; STA-2; STA2; ONO 11113
IUPAC/Chemical Name
5-Heptenoic acid, 7-((1S,2R,4R,5S)-3-((1E,3S)-3-hydroxy-1-octenyl)-6-thiabicyclo(3.1.1)hept-2-yl)-, (5Z)-
InChi Key
OVGWMUWIRHGGJP-WQQQDTQZSA-N
InChi Code
InChI=1S/C21H34O3S/c1-2-3-6-9-17(22)13-12-16-14-18-15-20(25-18)19(16)10-7-4-5-8-11-21(23)24/h4,7,12-13,16-20,22H,2-3,5-6,8-11,14-15H2,1H3,(H,23,24)/b7-4-,13-12+/t16?,17-,18-,19-,20-/m0/s1
SMILES Code
O=C(O)CCC/C=C\C[C@@H]1[C@@](C2)([H])S[C@@]2([H])CC1/C=C/[C@@H](O)CCCCC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 366.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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A Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Efficacy and Safety of STA-2 (Green Tea Polyphenols) in Patients with Chronic Stable Angina. Acta Cardiol Sin. 2016 Jul;32(4):439-49. PubMed PMID: 27471357; PubMed Central PMCID: PMC4963420. 5: Kondo K, Seo R, Omawari N, Imawaka H, Wakitani K, Kira H, Okegawa T, Kawasaki A. Effects of ONO-3708, an antagonist of the thromboxane A2/prostaglandin endoperoxide receptor, on blood vessels. Eur J Pharmacol. 1989 Sep 13;168(2):193-200. PubMed PMID: 2606148. 6: Zhang Y, Li W, Li L, Li Y, Fu R, Zhu Y, Li J, Zhou Y, Xiong S, Zhang H. Structural damage in the C. elegans epidermis causes release of STA-2 and induction of an innate immune response. Immunity. 2015 Feb 17;42(2):309-320. doi: 10.1016/j.immuni.2015.01.014. PubMed PMID: 25692704. 7: Lee SH, Omi S, Thakur N, Taffoni C, Belougne J, Engelmann I, Ewbank JJ, Pujol N. Modulatory upregulation of an insulin peptide gene by different pathogens in C. elegans. Virulence. 2018 Dec 31;9(1):648-658. doi: 10.1080/21505594.2018.1433969. PubMed PMID: 29405821; PubMed Central PMCID: PMC5955453. 8: Yamamoto K, Ebina S, Nakanishi H, Nakahata N. Thromboxane A2 receptor-mediated signal transduction in rabbit aortic smooth muscle cells. Gen Pharmacol. 1995 Nov;26(7):1489-98. PubMed PMID: 8690235. 9: Mais DE, Saussy DL Jr, Chaikhouni A, Kochel PJ, Knapp DR, Hamanaka N, Halushka PV. Pharmacologic characterization of human and canine thromboxane A2/prostaglandin H2 receptors in platelets and blood vessels: evidence for different receptors. J Pharmacol Exp Ther. 1985 May;233(2):418-24. PubMed PMID: 2987481. 10: Ikari A, Sakai H, Sato T, Takeguchi N. Thromboxane A2 receptor linked with the Ca2+ pathway in rat colonic crypt cells. Biochem Biophys Res Commun. 1999 May 19;258(3):708-12. PubMed PMID: 10329450. 11: Li BY, Qiao GF, Sun JP, Gao YR, Li WH. Inhibitory effects of ONO-3708 and S-145 on shape change and aggregation of rabbit platelets induced by STA2. Zhongguo Yao Li Xue Bao. 1996 Jul;17(4):345-8. PubMed PMID: 9812720. 12: Horikawa N, Suzuki T, Uchiumi T, Minamimura T, Tsukada K, Takeguchi N, Sakai H. Cyclic AMP-dependent Cl- secretion induced by thromboxane A2 in isolated human colon. J Physiol. 2005 Feb 1;562(Pt 3):885-97. Epub 2004 Dec 20. PubMed PMID: 15611029; PubMed Central PMCID: PMC1665535. 13: Coceani F, Liu Y, Seidlitz E, Kelsey L, Kuwaki T, Ackerley C, Yanagisawa M. Endothelin A receptor is necessary for O(2) constriction but not closure of ductus arteriosus. Am J Physiol. 1999 Oct;277(4):H1521-31. doi: 10.1152/ajpheart.1999.277.4.H1521. PubMed PMID: 10516191. 14: Seymour VR, Eschenroeder EC, Wright PA, Ashbrook SE. An NMR crystallographic approach to monitoring cation substitution in the aluminophosphate STA-2. Solid State Nucl Magn Reson. 2015 Feb;65:64-74. doi: 10.1016/j.ssnmr.2014.10.007. Epub 2014 Nov 4. PubMed PMID: 25465483. 15: Zamorano MF, Bhomia RK, Chimney MJ, Ivanoff D. Spatiotemporal changes in soil phosphorus characteristics in a submerged aquatic vegetation-dominated treatment wetland. J Environ Manage. 2018 Dec 15;228:363-372. doi: 10.1016/j.jenvman.2018.09.032. Epub 2018 Sep 18. PubMed PMID: 30241041. 16: Coe Y, Haleen SJ, Welch KM, Liu YA, Coceani F. The endothelin A receptor antagonists PD 156707 (CI-1020) and PD 180988 (CI-1034) reverse the hypoxic pulmonary vasoconstriction in the perinatal lamb. J Pharmacol Exp Ther. 2002 Aug;302(2):672-80. PubMed PMID: 12130731. 17: Sunano S, Li-Bo Z, Matsuda K, Sekiguchi F, Watanabe H, Shimamura K. Endothelium-dependent relaxation by alpha 2-adrenoceptor agonists in spontaneously hypertensive rat aorta. J Cardiovasc Pharmacol. 1996 May;27(5):733-9. PubMed PMID: 8859945. 18: Ito M, Nishikawa M, Fujioka M, Miyahara M, Isaka N, Shiku H, Nakano T. Characterization of the isoenzymes of cyclic nucleotide phosphodiesterase in human platelets and the effects of E4021. Cell Signal. 1996 Dec;8(8):575-81. PubMed PMID: 9115850. 19: Dodd W, Tang L, Lone JC, Wimberly K, Wu CW, Consalvo C, Wright JE, Pujol N, Choe KP. A Damage Sensor Associated with the Cuticle Coordinates Three Core Environmental Stress Responses in Caenorhabditis elegans. Genetics. 2018 Apr;208(4):1467-1482. doi: 10.1534/genetics.118.300827. Epub 2018 Feb 27. PubMed PMID: 29487136; PubMed Central PMCID: PMC5887142. 20: Kucera GL, Rittenhouse SE. Inhibition of GDP beta S of agonist-activated phospholipase C in human platelets requires cell permeabilization. Biochem Biophys Res Commun. 1988 May 31;153(1):417-21. PubMed PMID: 3377792.

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CCX2206

CCX2206