MedKoo Cat#: 565181 | Name: ULK-100

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ULK-100 is a potent ULK1 and ULK2 dual inhibitor.

Chemical Structure

ULK-100
ULK-100
CAS#NONE

Theoretical Analysis

MedKoo Cat#: 565181

Name: ULK-100

CAS#: NONE

Chemical Formula: C23H28F3N5O2S

Exact Mass: 495.1916

Molecular Weight: 495.57

Elemental Analysis: C, 55.75; H, 5.70; F, 11.50; N, 14.13; O, 6.46; S, 6.47

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
ULK100; ULK-100; ULK 100
IUPAC/Chemical Name
(S)-4-(6-(2-(Piperidin-1-yl)ethoxy)pyrazolo[1,5-a]pyrimidin-3-yl)-N-(1,1,1-trifluoro-3-methylbutan-2-yl)thiophene-2-carboxamide
InChi Key
IMPQRUJBTLVQMU-FQEVSTJZSA-N
InChi Code
InChI=1S/C23H28F3N5O2S/c1-15(2)20(23(24,25)26)29-22(32)19-10-16(14-34-19)18-12-28-31-13-17(11-27-21(18)31)33-9-8-30-6-4-3-5-7-30/h10-15,20H,3-9H2,1-2H3,(H,29,32)/t20-/m0/s1
SMILES Code
O=C(C1=CC(C2=C3N=CC(OCCN4CCCCC4)=CN3N=C2)=CS1)N[C@@H](C(C)C)C(F)(F)F
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 495.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Martin KR, Celano SL, Solitro AR, Gunaydin H, Scott M, O'Hagan RC, Shumway SD, Fuller P, MacKeigan JP. A Potent and Selective ULK1 Inhibitor Suppresses Autophagy and Sensitizes Cancer Cells to Nutrient Stress. iScience. 2018 Oct 26;8:74-84. doi: 10.1016/j.isci.2018.09.012. Epub 2018 Sep 19. PubMed PMID: 30292171; PubMed Central PMCID: PMC6172447.