Chlorfluazuron | CAS# 71422-67-8 | Chitin Synthesis Inhibitor

MedKoo Cat#: 573539 | Name: Chlorfluazuron

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Chlorfluazuron is a chitin synthesis inhibitor. Chlorfluazuron is commonly used in agriculture as an insect growth regulator for controlling the major insect pests in crops

Chemical Structure

Chlorfluazuron

CAS#71422-67-8

Theoretical Analysis

MedKoo Cat#: 573539

Name: Chlorfluazuron

CAS#: 71422-67-8

Chemical Formula: C20H9Cl3F5N3O3

Exact Mass: 538.9630

Molecular Weight: 540.65

Elemental Analysis: C, 44.43; H, 1.68; Cl, 19.67; F, 17.57; N, 7.77; O, 8.88

Price and Availability

Size	Price	Availability	Quantity
1g	USD 450.00	2 Weeks

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Related CAS #

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Synonym

AI3-29785, Atabron, CCRIS 2680, CGA 112913, Chlorfluazuron, IKI 7899, PP 145, UC 62644

IUPAC/Chemical Name

Benzamide, N-(((3,5-dichloro-4-((3-chloro-5-(trifluoromethyl)-2-pyridinyl)oxy)phenyl)amino)carbonyl)-2,6-difluoro-

InChi Key

UISUNVFOGSJSKD-UHFFFAOYSA-N

InChi Code

1S/C20H9Cl3F5N3O3/c21-10-5-9(30-19(33)31-17(32)15-13(24)2-1-3-14(15)25)6-11(22)16(10)34-18-12(23)4-8(7-29-18)20(26,27)28/h1-7H,(H2,30,31,32,33)

SMILES Code

c1cc(c(c(c1)F)C(=O)NC(=O)Nc2cc(c(c(c2)Cl)Oc3c(cc(cn3)C(F)(F)F)Cl)Cl)F

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 540.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Li H, Zhong Q, Wang X, Luo F, Zhou L, Sun H, Yang M, Lou Z, Chen Z, Zhang X. The degradation and metabolism of chlorfluazuron and flonicamid in tea: A risk assessment from tea garden to cup. Sci Total Environ. 2021 Feb 1;754:142070. doi: 10.1016/j.scitotenv.2020.142070. Epub 2020 Aug 29. PMID: 32920390. 2: Cho S, Kim J, Lee S, Kim TH. Crystal structure of chlorfluazuron. Acta Crystallogr E Crystallogr Commun. 2015 Jan 1;71(Pt 1):o55. doi: 10.1107/S2056989014026632. PMID: 25705506; PMCID: PMC4331875. 3: Wan Umar WAS, Ab Majid AH. Efficacy of Minimum Application of Chlorfluazuron Baiting to Control Urban Subterranean Termite Populations of Coptotermes gestroi (Wasmann) (Blattodea: Rhinotermitidae). Insects. 2020 Aug 25;11(9):569. doi: 10.3390/insects11090569. PMID: 32854188; PMCID: PMC7564584. 4: Huang Q, Wu X, Yu X, Zhang L, Lu M, Tao L. Comparison of the cytotoxic impact of chlorfluazuron on selected insect and human cell lines. Environ Toxicol Chem. 2015 Jul;34(7):1675-82. doi: 10.1002/etc.2969. Epub 2015 May 14. PMID: 25753780. 5: Ganguly P, Barik SR, Patra S, Roy S, Bhattacharyya A. Persistence of chlorfluazuron in cabbage under different agro-climatic conditions of India and its risk assessment. Environ Toxicol Chem. 2017 Nov;36(11):3028-3033. doi: 10.1002/etc.3872. Epub 2017 Jul 17. PMID: 28574603. 6: Sun M, Tong Z, Dong X, Chu Y, Wang M, Gao T, Duan J. Determination of the Residue Behavior and Risk Assessment of Chlorfluazuron in Chinese Cabbage, Kale, Lettuce and Cauliflower by UPLC-MS/MS. Int J Environ Res Public Health. 2019 May 17;16(10):1758. doi: 10.3390/ijerph16101758. PMID: 31108982; PMCID: PMC6571697. 7: Guo HF, Fang JC, Liu BS, Wang JP, Zhong WF, Wan FH. Enhancement of the biological activity of nucleopolyhedrovirus through disruption of the peritrophic matrix of insect larvae by chlorfluazuron. Pest Manag Sci. 2007 Jan;63(1):68-74. doi: 10.1002/ps.1316. PMID: 17103370. 8: Hussein HS, Eldesouky SE. Insecticidal, Behavioral and Biological Effects of Chlorantraniliprole and Chlorfluazuron on Cotton Leafworm (Spodoptera littoralis). Pak J Biol Sci. 2019 Jan;22(8):372-382. doi: 10.3923/pjbs.2019.372.382. PMID: 31930825. 9: Zhang P, Zhao YH, Wang QH, Mu W, Liu F. Lethal and sublethal effects of the chitin synthesis inhibitor chlorfluazuron on Bradysia odoriphaga Yang and Zhang (Diptera: Sciaridae). Pestic Biochem Physiol. 2017 Mar;136:80-88. doi: 10.1016/j.pestbp.2016.07.007. Epub 2016 Jul 26. PMID: 28187835. 10: Rabea EI, Nasr HM, Badawy ME. Toxic effect and biochemical study of chlorfluazuron, oxymatrine, and spinosad on honey bees (Apis mellifera). Arch Environ Contam Toxicol. 2010 Apr;58(3):722-32. doi: 10.1007/s00244-009-9403-y. Epub 2009 Oct 8. PMID: 19812878. 11: Shim JH, Abd El-Aty AM, Choi JH, Choi YS. Post-harvest HPLC determination of chlorfluazuron residues in pears treated with different programs. Biomed Chromatogr. 2007 Jul;21(7):695-700. doi: 10.1002/bmc.807. PMID: 17428007. 12: Choi JH, Mamun MI, Park JH, Shin EH, Shim JH. Determination of field- incurred chlorfluazuron residues in the peach. Bull Environ Contam Toxicol. 2011 Mar;86(3):331-5. doi: 10.1007/s00128-011-0191-5. Epub 2011 Feb 15. PMID: 21327612. 13: Manzoor F, Pervez M. Evaluation of Chlorfluazuron Against Subterranean Termites Heterotermes indicola (Isoptera: Rhinotermitidae) in Pakistan. J Econ Entomol. 2016 Dec 1;109(6):2264-2271. doi: 10.1093/jee/tow211. PMID: 27744282. 14: Rust MK, Hemsarth WL. Intrinsic Activity of IGRs Against Larval Cat Fleas. J Med Entomol. 2017 Mar 1;54(2):418-421. doi: 10.1093/jme/tjw201. PMID: 28011733. 15: Spence SA, Murison R, Harden S. Rate of decline of chlorfluazuron concentration in the fat of cattle. Aust Vet J. 1998 Jan;76(1):54-6. doi: 10.1111/j.1751-0813.1998.tb15687.x. PMID: 9578769. 16: Lee CC, Neoh KB, Lee CY. Colony Size Affects the Efficacy of Bait Containing Chlorfluazuron Against the Fungus-Growing Termite Macrotermes gilvus (Blattodea: Termitidae). J Econ Entomol. 2014 Dec;107(6):2154-62. doi: 10.1603/EC14193. PMID: 26470081. 17: Quesada BL, Montoya-Lerma J. Laboratory evaluation of chlorfluazuron against larval phlebotomine sand flies (Diptera: Psychodidae). J Econ Entomol. 1994 Oct;87(5):1129-32. doi: 10.1093/jee/87.5.1129. PMID: 7962946. 18: Peters BC, Fitzgerald CJ. Field evaluation of the bait toxicant chlorfluazuron in eliminating Coptotermes acinaciformis (Froggatt) (Isoptera: Rhinotermitidae). J Econ Entomol. 2003 Dec;96(6):1828-31. doi: 10.1093/jee/96.6.1828. PMID: 14977122. 19: Armishaw P, Ward J, Millar RG. Development of a reference material for residues of chlorfluazuron and fluazuron in beef fat ACSL CRM 3Part I. Preparation, homogeneity and stabilit. Anal Bioanal Chem. 1996 Aug;356(1):10-2. doi: 10.1007/s0021663560010. PMID: 15045250. 20: Wang J, Zheng X, Yuan J, Wang S, Xu B, Wang S, Zhang Y, Wu Q. Insecticide Resistance Monitoring of the Diamondback Moth (Lepidoptera: Plutellidae) Populations in China. J Econ Entomol. 2021 Jun 11;114(3):1282-1290. doi: 10.1093/jee/toab027. PMID: 33728433.

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