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MedKoo Cat#: 565178 | Name: Clothianidin
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Clothianidin is an insecticide which acts as an agonist of acetylcholine, thereby stimulating nAChR and activating post-synaptic acetylcholine receptors but not inhibiting AChE.

Chemical Structure

Clothianidin
Clothianidin
CAS#210880-92-5

Theoretical Analysis

MedKoo Cat#: 565178

Name: Clothianidin

CAS#: 210880-92-5

Chemical Formula: C6H8ClN5O2S

Exact Mass: 249.0087

Molecular Weight: 249.67

Elemental Analysis: C, 28.86; H, 3.23; Cl, 14.20; N, 28.05; O, 12.82; S, 12.84

Price and Availability

Size Price Availability Quantity
50mg USD 285.00 2 Weeks
100mg USD 500.00 2 Weeks
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Related CAS #
No Data
Synonym
TI 435; TI435; TI-435; Celero; Clothianidin; Clothianidin; Poncho; Dantotsu; Fullswing; Apacz; Clutch; (E)-clothianidin
IUPAC/Chemical Name
1-[(2-Chloro-1,3-thiazol-5-yl)methyl]-2-methyl-3-nitroguanidine
InChi Key
PGOOBECODWQEAB-UHFFFAOYSA-N
InChi Code
InChI=1S/C6H8ClN5O2S/c1-8-6(11-12(13)14)10-3-4-2-9-5(7)15-4/h2H,3H2,1H3,(H2,8,10,11)
SMILES Code
O=[N+](N/C(NCC1=CN=C(Cl)S1)=N\C)[O-]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 249.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Montiel-León JM, Munoz G, Vo Duy S, Do DT, Vaudreuil MA, Goeury K, Guillemette F, Amyot M, Sauvé S. Widespread occurrence and spatial distribution of glyphosate, atrazine, and neonicotinoids pesticides in the St. Lawrence and tributary rivers. Environ Pollut. 2019 Apr 2;250:29-39. doi: 10.1016/j.envpol.2019.03.125. [Epub ahead of print] PubMed PMID: 30981933. 2: Bonmatin JM, Noome DA, Moreno H, Mitchell EAD, Glauser G, Soumana OS, Bijleveld van Lexmond M, Sánchez-Bayo F. A survey and risk assessment of neonicotinoids in water, soil and sediments of Belize. Environ Pollut. 2019 Mar 26;249:949-958. doi: 10.1016/j.envpol.2019.03.099. [Epub ahead of print] PubMed PMID: 30965547. 3: Harry-Asobara JL, Kamei I. Indirect bacterial effect enhanced less recovery of neonicotinoids by improved activities of white-rot fungus Phlebia brevispora. J Microbiol Biotechnol. 2019 Mar 28. doi: 10.4014/jmb.1809.09051. [Epub ahead of print] PubMed PMID: 30955256. 4: Schaafsma AW, Limay-Rios V, Baute TS, Smith JL. Neonicotinoid insecticide residues in subsurface drainage and open ditch water around maize fields in southwestern Ontario. PLoS One. 2019 Apr 4;14(4):e0214787. doi: 10.1371/journal.pone.0214787. eCollection 2019. PubMed PMID: 30947236; PubMed Central PMCID: PMC6449027. 5: Parte SG, Kharat AS. Aerobic Degradation of Clothianidin to 2-Chloro-methyl Thiazole and Methyl 3-(Thiazole-yl) Methyl Guanidine Produced by Pseudomonas stutzeri smk. J Environ Public Health. 2019 Mar 3;2019:4807913. doi: 10.1155/2019/4807913. eCollection 2019. PubMed PMID: 30944570; PubMed Central PMCID: PMC6421824. 6: Morfin N, Goodwin PH, Hunt GJ, Guzman-Novoa E. Effects of sublethal doses of clothianidin and/or V. destructor on honey bee (Apis mellifera) self-grooming behavior and associated gene expression. Sci Rep. 2019 Mar 26;9(1):5196. doi: 10.1038/s41598-019-41365-0. PubMed PMID: 30914660; PubMed Central PMCID: PMC6435647. 7: Graves EE, Jelks KA, Foley JE, Filigenzi MS, Poppenga RH, Ernest HB, Melnicoe R, Tell LA. Analysis of insecticide exposure in California hummingbirds using liquid chromatography-mass spectrometry. Environ Sci Pollut Res Int. 2019 Apr 2. doi: 10.1007/s11356-019-04903-x. [Epub ahead of print] PubMed PMID: 30941712. 8: Bartlett AJ, Hedges AM, Intini KD, Brown LR, Maisonneuve FJ, Robinson SA, Gillis PL, de Solla SR. Acute and chronic toxicity of neonicotinoid and butenolide insecticides to the freshwater amphipod, Hyalella azteca. Ecotoxicol Environ Saf. 2019 Jul 15;175:215-223. doi: 10.1016/j.ecoenv.2019.03.038. Epub 2019 Mar 20. PubMed PMID: 30901639. 9: Ngwej LM, Hattingh I, Mlambo G, Mashat EM, Kashala JK, Malonga FK, Bangs MJ. Indoor residual spray bio-efficacy and residual activity of a clothianidin-based formulation (SumiShield(®) 50WG) provides long persistence on various wall surfaces for malaria control in the Democratic Republic of the Congo. Malar J. 2019 Mar 12;18(1):72. doi: 10.1186/s12936-019-2710-5. PubMed PMID: 30866934; PubMed Central PMCID: PMC6417189. 10: Gavel MJ, Richardson SD, Dalton RL, Soos CE, Ashby B, McPhee L, Forbes MR, Robinson SA. Effects of two neonicotinoid insecticides on blood cell profiles and corticosterone concentrations of wood frogs (Lithobates sylvaticus). Environ Toxicol Chem. 2019 Mar 22. doi: 10.1002/etc.4418. [Epub ahead of print] PubMed PMID: 30901102. 11: Filigenzi MS, Graves EE, Tell LA, Jelks KA, Poppenga RH. Quantitation of neonicotinoid insecticides, plus qualitative screening for other xenobiotics, in small-mass avian tissue samples using UHPLC high-resolution mass spectrometry. J Vet Diagn Invest. 2019 Mar 11:1040638719834329. doi: 10.1177/1040638719834329. [Epub ahead of print] PubMed PMID: 30853007. 12: Colgan TJ, Fletcher IK, Arce AN, Gill RJ, Ramos Rodrigues A, Stolle E, Chittka L, Wurm Y. Caste- and pesticide-specific effects of neonicotinoid pesticide exposure on gene expression in bumblebees. Mol Ecol. 2019 Mar 6. doi: 10.1111/mec.15047. [Epub ahead of print] PubMed PMID: 30843300. 13: Wang Y, Zhang Y, Zeng T, Li W, Yang L, Guo B. Accumulation and toxicity of thiamethoxam and its metabolite clothianidin to the gonads of Eremias argus. Sci Total Environ. 2019 Jun 1;667:586-593. doi: 10.1016/j.scitotenv.2019.02.419. Epub 2019 Feb 28. PubMed PMID: 30833257. 14: Tadei R, Domingues CEC, Malaquias JB, Camilo EV, Malaspina O, Silva-Zacarin ECM. Late effect of larval co-exposure to the insecticide clothianidin and fungicide pyraclostrobin in Africanized Apis mellifera. Sci Rep. 2019 Mar 1;9(1):3277. doi: 10.1038/s41598-019-39383-z. PubMed PMID: 30824742; PubMed Central PMCID: PMC6397237. 15: Kammoun S, Mulhauser B, Aebi A, Mitchell EAD, Glauser G. Ultra-trace level determination of neonicotinoids in honey as a tool for assessing environmental contamination. Environ Pollut. 2019 Apr;247:964-972. doi: 10.1016/j.envpol.2019.02.004. Epub 2019 Feb 5. PubMed PMID: 30823351. 16: Pietrzak D, Wątor K, Pękała D, Wójcik J, Chochorek A, Kmiecik E, Kania J. LC-MS/MS method validation for determination of selected neonicotinoids in groundwater for the purpose of a column experiment. J Environ Sci Health B. 2019 Mar 1:1-8. doi: 10.1080/03601234.2019.1574173. [Epub ahead of print] PubMed PMID: 30821594. 17: Dagg K, Irish S, Wiegand RE, Shililu J, Yewhalaw D, Messenger LA. Evaluation of toxicity of clothianidin (neonicotinoid) and chlorfenapyr (pyrrole) insecticides and cross-resistance to other public health insecticides in Anopheles arabiensis from Ethiopia. Malar J. 2019 Feb 22;18(1):49. doi: 10.1186/s12936-019-2685-2. PubMed PMID: 30795768; PubMed Central PMCID: PMC6387473. 18: Gui T, Jia GF, Xu J, Ge SJ, Long XF, Zhang YP, Hu Y. Determination of the residue dynamics and dietary risk of thiamethoxam and its metabolite clothianidin in citrus and soil by LC-MS/MS. J Environ Sci Health B. 2019 Feb 17:1-10. doi: 10.1080/03601234.2019.1571361. [Epub ahead of print] PubMed PMID: 30773126. 19: Hyland C, Bradman A, Gerona R, Patton S, Zakharevich I, Gunier RB, Klein K. Organic diet intervention significantly reduces urinary pesticide levels in U.S. children and adults. Environ Res. 2019 Apr;171:568-575. doi: 10.1016/j.envres.2019.01.024. Epub 2019 Feb 12. PubMed PMID: 30765100. 20: Jin R, Mao K, Liao X, Xu P, Li Z, Ali E, Wan H, Li J. Overexpression of CYP6ER1 associated with clothianidin resistance in Nilaparvata lugens (Stål). Pestic Biochem Physiol. 2019 Feb;154:39-45. doi: 10.1016/j.pestbp.2018.12.008. Epub 2018 Dec 18. PubMed PMID: 30765055.